CBD Oil For Migraines Reddit

Dr. Stephen Silberstein outlines what patients should know about CBD oil as a treatment for migraine, including effects and regulations. Medical Cannabis, Headaches, and Migraines: A Review of the Current Literature This is an open access article distributed under the terms of the Creative Commons Attribution License, which CBD is a popular option for people looking for natural ways to treat pain and discomfort, including chronic headaches and migraines.

Migraine and CBD Oil

Dr. Stephen Silberstein outlines what patients should know about CBD oil as treatment for migraine

Cannabidiol has taken the U.S. by storm recently. Commonly known as CBD, the active ingredient found in the cannabis, or marijuana, plant, is becoming increasingly available through online retailers, with claims of pain and inflammation reduction. And those living with migraine have taken notice.

In an effort to understand the benefits and risks of using CBD oil for migraine, we recently spoke with Dr. Stephen Silberstein, director of the Headache Center at Jefferson University Hospital in Philadelphia.

The Effects of CBD

Unlike THC, another widely known derivative of the cannabis plant, CBD oil does not have psychoactive properties or effects. “It works locally, and even if taken orally, it won’t produce intoxication,” says Dr. Silberstein.

There is no scientific evidence or research on CBD as an effective treatment for migraine—in large part because it has not been formally studied. However, it may still be a viable topical option for some patients with joint and muscle pain associated with migraine. “If you have a lot of neck pain or soreness, it is perfectly reasonable to use CBD oil. It may even prevent nausea and vomiting,” Dr. Silberstein says.

Despite the fact that CBD oil does not elicit the same response as marijuana, it is not legal in all 50 states. So one side-effect could be the legal ramifications of partaking in using CBD oil in a state where it is not permitted by law. To determine if it is legal in the state where you reside, visit Americans for Safe Access.

Lack of Regulation

For patients interested in CBD oil for the acute treatment of migraine, Dr. Silberstein says it is important to ensure that you are using a pure product. You are likely to receive a pure and safe product in states where CBD oil is legal and grown. Local dispensaries will also be of use in determining origin and quality.

Dr. Silberstein advises against obtaining a product in states in which CBD oil is not currently legal or regulated. Illegal forms of CBD oil could be spiked with artificial THC which could be very harmful to patients. Additionally, there are legal implications if you attempt to purchase it where it is currently illegal, so it is important to speak with your healthcare provider and check your local and state laws.

Consult a Physician

Before beginning any treatment, it is important that you consult your healthcare provider and be open and honest about your plans. Having a strong doctor-patient relationship is key to establishing trust and determining an effective treatment plan that takes into account your lifestyle. “These drugs do interact with the body,” Dr. Silberstein says. “If you’re getting funny symptoms and you’re taking something that the doctor doesn’t know about, how’s he going to help you?”

Dr. Silberstein also cautions against CBD oil or marijuana in use in adolescents, as it may affect the developing brain. “In general, it should be avoided by adolescents until more research has been conducted,” he adds.

For more information on treatments for migraine, visit our doctor-verified resource library. You can also use our find a doctor tool to find a headache specialist in your area.

Reviewed for accuracy by the American Migraine Foundation’s subject matter experts, headache specialists and medical advisers with deep knowledge and training in headache medicine. Click here to read about our editorial board members.

Medical Cannabis, Headaches, and Migraines: A Review of the Current Literature

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cannabis has been long used since ancient times for both medical and recreational use. Past research has shown that cannabis can be indicated for symptom management disorders, including cancer, chronic pain, headaches, migraines, and psychological disorders (anxiety, depression, and post-traumatic stress disorder). Active ingredients in cannabis that modulate patients’ perceptions of their conditions include Δ 9 ‐tetrahydrocannabinol (THC), cannabidiol (CBD), flavonoids, and terpenes. These compounds work to produce effects within the endocannabinoid system to decrease nociception and decrease symptom frequency. Research within the United States of America is limited to date due to cannabis being classified as a schedule one drug per the Drug Enforcement Agency. Few anecdotal studies have found a limited relationship between cannabis use and migraine frequency. The purpose of the review article is to document the validity of how medical cannabis can be utilized as an alternative therapy for migraine management. Thirty-four relevant articles were selected after a thorough screening process using PubMed and Google Scholar databases. The following keywords were used: “Cannabis,” “Medical Marijuana,” “Headache,” “Cannabis and Migraine,” “Cannabis and Headache.” This literature study demonstrates that medical cannabis use decreases migraine duration and frequency and headaches of unknown origin. Patients suffering from migraines and related conditions may benefit from medical cannabis therapy due to its convenience and efficacy.

Introduction and background

Cannabis has a rooted history for both medical and recreational use. Cannabis has been used since ancient times to manage various conditions, including acute pain, anxiety, cancer pain, chronic pain, depression, headaches, and migraines [1]. It exists in forms that include: Cannabis indica, Cannabis ruderalis, and Cannabis sativa of which contain 400 compounds [2]. Important compounds of interest include Δ 9 ‐tetrahydrocannabinol (THC), cannabidiol (CBD), flavonoids, and terpenes [2]. THC and CBD are the major components of different medical cannabis formulations [2]. Both CBD and THC stimulate cannabinoid (CB) receptors throughout the human body, constituting the endocannabinoid system [2]. The endocannabinoid system consists of CB1 (central/peripheral nervous system) and CB2 (peripheral/immune tissues) receptors [2]. CB1 receptor activation leads to decreased neurotransmission of dopamine, γ-aminobutyric acid (GABA), and glutamate. On the other hand, CB2 receptor activation leads to analgesia and decreased immune system function [2-4].

In migraines, current theory suggests that the CB system mitigates migraine through several pathways (glutamine, inflammatory, opiate, and serotonin) both centrally and peripherally [4]. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment; it is active in the periaqueductal gray matter, a migraine generator. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects [5]. Furthermore, cannabinoids may have a specific prophylactic effect in migraines due to their ability to inhibit platelet serotonin release and peripheral vasoconstrictor effect [6]. In addition, CB1 receptors reduce nociperception via a serotonin-mediated pathway, whereas CB2 receptors act to produce analgesia without developing tolerance or side effects [4]. Current research suggests that the endocannabinoid system plays a role in migraine mitigation, but updated research is lacking within the United States of America (USA) [7,8].

Cannabis is classified as a Schedule I drug, per the Controlled Substances Act and the Drug Enforcement Agency, indicating that it has a high potential for abuse, and medical use is prohibited [9,10]. However, state governments have utilized their powers and legalized cannabis for medical and/or legal use within the last several years. California was the first state to legalize medical cannabis back in 1996 [9]. Still, to date, 36 states and four USA territories deem this compound for medical use, with 18 states, two territories, and the District of Colombia allowing it for recreational use [9]. Medical societies have even incorporated cannabis use in medical management. For example, the Canadian Pain Society recommended back in 2014 that cannabis be utilized as third-line therapy for chronic pain management [11]. Chronic pain is often a common reason for a patient to register with a medical cannabis state registry [12]. Other uses for medical cannabis include symptom management of Alzheimer’s disease, amyotrophic lateral sclerosis, migraines, multiple sclerosis, and seizures [4,13,14]. To utilize medical cannabis, an individual must establish care with a medical cannabis physician and have a qualifying or similar diagnosis [15]. Florida, for example, requires that a patient have a qualifying medical condition that includes, amyotrophic lateral sclerosis, cancer, chronic nonmalignant pain, Crohn’s disease, epilepsy, glaucoma, human immunodeficiency virus disease/acquired immunodeficiency disease syndrome, multiple sclerosis, Parkinson’s disease, post-traumatic stress disorder, and terminal condition [12,15]. In addition, as defined per Florida amendment 2, similar conditions include disorders (alcoholism, anxiety, depression, diabetes, and endometriosis) that have symptoms that are common to the above qualifying conditions [12]. Once a physician determines patient eligibility for medical cannabis use, a patient can access medical cannabis products for seven months [12].

Medical research for medical cannabis use is sparse, given the lack of randomized control studies. Current literature is limited to case reports, case series, cell phone survey applications, and retrospective analyses. In addition, few studies document the improvement of migraine symptoms with medical cannabis use. However, two prospective trials done by Robins et al. and Aviram et al. have noted migraine improvement within their studies [16,17]. Also, there are limited studies that qualify or quantify an ideal dosage and method of cannabis use. Hence, with minimal research studies on the effectiveness of medical cannabis on different medical conditions, review papers are essential to summarize how this compound can be effective in headache and migraine management.

This paper aims to determine if medical cannabis can be utilized as an alternative treatment for headache and migraine management. It emphasizes how medical cannabis can reduce headaches and migraine duration and frequency, highlights different forms and ideal doses used for clinical effectiveness. After an extensive literature search using PubMed and Google scholar databases, 34 relevant articles were found to review the efficacy of medical marijuana use on migraines and headaches. Keywords used were “Cannabis,” “Medical Marijuana,” “headache,” “Cannabis and Migraine,” “Cannabis and Headache.” The articles were thoroughly screened by reviewing each article with titles, abstracts, and content of the full articles. We included the studies published between 1987 and 2020, human studies in the English language, including adults 18 years and older, whereas articles involving children less than 17 years and pregnant females were excluded from this study.

Review

Cannabinoids, similar to other analgesics and recreational drugs, act on the brain’s reward system, especially on cannabinoid one receptor localized at the same place as opioid receptors on nucleus accumbens and functions by overlapping the antinociceptive pathways [18]. Articles included in our study focused on identifying the cannabis treatment in migraines and headaches. These articles also analyzed the preferred cannabis forms and their substitution for medications. During the extensive search of the literature, we came across three main questions for which the studies are conducted and directed: (i) Is medical cannabis effective on headaches and migraines? (ii) What forms of medical cannabis do people prefer? (iii) What is an ideal dose for the “preferred form?”

See also  Botanicals CBD Oil For Dogs

Medical cannabis and its potential role in headaches and migraines

Several studies have reported both the benefits and effectiveness of medical cannabis use. A prospective clinical trial done in 2020 by Aviram et al. focused on 68 patients who smoked or vaped MC inflorescences evaluated the differences in total MC monthly dose between responders and non‐responders [17]. This study focused on the associations between phytocannabinoid treatment and migraine frequency [17]. The study also reported better migraine symptom reduction, less negative headache impact, better sleep quality, and decreased medication consumption [17]. In 2019, Cuttler et al., in their survey study from a Canadian data application (Strainprint), focused on the inhaled cannabis usage and their effect of reduction in migraine severity and frequency along with the factors affecting the dosage used [19]. Survey results demonstrated that headaches were reduced by 47.3% and migraines by 49.6% [19]. A higher proportion of males (90.9%) compared to females (89.1%) reported a more favorable reduction with headaches, whereas females (88.6) compared to males (87.3%) reported a more favorable reduction with migraines [19]. It also investigated the tolerance development with prolonged cannabis use [19]. Lack of a control group and sampling bias were limitations of this study [19]. In 2018, Baron et al. did a literature review of cannabinoid usage to treat migraines, facial pain, and chronic pain and their medicinal benefits [20]. The study shows the significant advantage of medical marijuana in improving nausea and vomiting associated with migraines [20]. Later in 2018, he and his team conducted another survey and identified different patterns of medical marijuana treatment in migraine headaches [20]. Rhyne et al., in 2016, did a retrospective study from medical record reviews, analyzed the frequency of headaches with medical marijuana as a primary goal, and focused on the type, dosage use, previous migraine therapies used, and patient-reported data as secondary outcomes [21]. They showed a significant reduction in migraine frequency with medical marijuana [21]. Leroux et al. conducted a survey and demonstrated that the prevalence of cannabis use is higher in patients with cluster headaches than in the general population [22]. The study included 139 patients from two hospitals in France and attempted to investigate the frequency of cannabis use among cluster headache sufferers and its effects on attacks [22]. Medical cannabis was found to have unpredictable effects in 1/2 of all the patients with cluster headaches, a modest effect in 1/4 of all patients, and eliminate an attack in 1/8 of patients [22]. Due to cannabis’s variable responses, the survey concluded that cannabis should not be used as a therapeutic option for managing cluster headache attacks [22]. Bagshaw et al. in 2002 provided a literature review with a summary of recommendations of when medical cannabis can be used in the palliative care setting [23]. The literature review focused on symptoms in palliative care not limited to nausea, migraines, muscle spasticity, and seizures [23]. This review found that oral THC was superior to placebo for managing symptoms. THC use, however, was found to be limited due to dose-dependent psychosis and psychotropic effects [23]. Pini et al., in their randomized controlled trial (RCT) study, evaluated the efficacy and safety of nabilone in reducing pain and frequency of headache, the number of analgesic intake, and in increasing the quality of life of patients with long-standing intractable medication overuse headache [24].

Despite mixed findings regarding the effectiveness of medical cannabis on both headaches and migraines, there is a consensus for the indication of medical marijuana therapy when first and second-line treatment fails. Current ethnobotanical and anecdotal references mention efficacy. Biochemical studies of THC and anandamide have provided a scientific basis for both symptomatic and prophylactic treatment of migraine [25]. Dronabinol and nabilone, synthetic cannabinoids, have been shown to act in place of first-line therapy for cluster headaches (triptans, verapamil) and can effectively control pain [16,26]. Non-synthetic cannabis (oral, inhaled, sublingual, edible, topical) can be indicated for managing headache and migraine symptoms, but it is dose-dependent [22,23]. Adverse reactions to medical cannabis use can include dizziness, dry mouth or eyes, nausea, vomiting, and psychosis [26]. Despite such side effects, patients have an overall favorable view of using medical cannabis along with or in place of medications, as it was reported to decrease the frequency and duration of migraines.

Different forms of medical cannabis and patients preference

Several studies have reported preferred forms of medical cannabis for the treatment of migraines and headaches. Salazar et al. conducted a cross-sectional survey to assess self-reported reasons for recreational and medical cannabis users in the southeastern United States [27]. From the survey, 50 participants (11.6%) reported medical cannabis use, 180 participants (41.7%) reported recreational use, and 202 participants (46.8%) reported combined usage [27]. The reported primary method of use was smoking, followed by vaporization (5.6%) and “dabs” (2.8%) [27]. Participants were asked about their cannabis use, frequency, amount, and methods to use it [27]. The survey’s results showed that 35.5% of the patients used it for headaches and migraines [27]. The effect of medicinal cannabis on headaches and other conditions had a mean score of 3.6/5, which meant an 86% efficacy in pain relief [27]. The dried Cannabis flower may be an effective medication for the treatment of migraine- and headache-related pain, but the effectiveness differs according to characteristics of the Cannabis plant, the combustion methods, and the age and gender of the patient [28]. Many patients were able to replace their pain meds with medicinal cannabis in a survey reported by Nicolodi et al. [29]. Limitations of this study include relying upon self-reported data along with a lack of diagnosis verification [29]. Boehnke et al., in 2019, conducted an online survey consisting of 1321 patients on medicinal cannabis use [30]. This survey analyzes cannabis use patterns among chronic pain patients [30]. More females, 59.1%, participated in the survey in comparison to male patients [30]. Males use smoke and vaporize form more, whereas females rank edible, tincture (oil-based), and topical cannabis as preferred first-line methods and also products that consist of low THC to high CBD in a “ratio” [30]. Piper et al., in 2017, conducted an online survey to evaluate the effects of medical cannabis usage by substituting opioids or other psychoactive medications and evaluated the communication about the usage of the patients with their physician [31]. This survey included 52.9% female and 47.1% male patients [31]. The results show that 76.7% reported a gradual decrease in opiate use [31]. Approximately, two-thirds of patients reduced anti-anxiety, migraine medications, antidepressants, and alcohol following MC usage [31]. Preferred delivery methods include joints (48.5%), vaporization (22.3%), edibles (14.3%), tinctures (10.8%), concentrates (3.4%), and topical (0.7%) methods [31]. This survey is limited as it did not examine “combination” medication use (antidepressant + sleep aid), and the data were designed to be interpretable by the general population [31]. Rhyne et al., in 2016, conducted a retrospective, observational review of patients in Colorado [21]. Patients between the ages of 18 and 89 years old with a diagnosis of migraines were included in the study [21]. Factors such as sex, the duration of migraines, medical history, past migraine treatment, number of migraines experienced per month, how often and how much cannabis was used were self-reported by the patient [21]. It was reported that out of 82, 20 patients used at least two forms of cannabis [21]. The study has shown different forms of cannabis used to treat migraines [21].

After reviewing the literature, it is found that the primary method for cannabis use was smoking, followed by vaporization (5.6%) and dabs (2.8%) [27]. Patients with headaches were 2.7 times more likely to prefer a hybrid (Cannabis sativa + Cannabis indica) strain than chronic pain patients [20]. Females preferred to rank edible, tincture (oil-based), and topical cannabis as preferred first-line methods for chronic pain like arthritis and migraine [30]. Also, analysis of Strainprint responses reveals that inhalation methods like smoking, vaping, concentrates, dabs (79.4% of headache data and 82.8% of migraine data) were primary methods used by the patients [19].

Cannabis ideal dose and preferred forms

While medical cannabis exists in different forms, there is variability in the ideal dosage for medical cannabis use. Several studies done to determine the “ideal” dosage are described here. Ogborne et al., in 2000, interviewed 50 medical cannabis users recruited via advertisements in newspapers and job boards [26]. The participants were using medical cannabis for various reasons such as HIV, cramps, depression, pain, and migraines [26]. Almost all of the participants smoked cannabis approximately two to three times a day [26]. Baron et al., in 2018, in their electronic survey for the use of medical cannabis in a patient with headache, showed a pattern of cannabis use, including frequency, quantity, and strains [20]. In the ID Migraine™ questionnaire, hybrid strains of cannabis, of which “OG Shark,” a high THC/THCA, low CBD/CBDA, and strains with predominant terpenes β-caryophyllene and β-myrcene, were most preferred in the headache and migraine groups [20]. In the study trial, patients were intervened with 19% THC or THC+ 9% CBD [20]. It was found that a dose of 200 mg effectively reduced the intensity of migraine pain by 55% [20]. In another phase, 25 mg of amitriptyline or THC+CBD 200 mg per day was given prophylactically for three months in chronic migraine patients [20]; also, THC + CBD 200 mg was required for the acute attack [20]. The study concluded that THC + CBD 200 mg had a 40.4% improvement over amitriptyline use (40.1%) [20]. A similar study was done for the cluster headache, but it did not benefit as abortive treatment [20]. Sexton et al., in 2016, did an online survey that sought to collect epidemiological data to start a discussion on medico-legal recommendations, report patient outcomes, and inform the medical practice of medical cannabis users [32]. Many medical professionals (59.8%) used cannabis as an alternative treatment for their patients, reducing the symptoms by 86% [32]. This study also included the route and dosage of medical marijuana usage, where 84.1% of the participants had inhalation as the most common route, and 60.8% of the participants reported one to five hits usage per session [32]. Concerning the dosage of cannabis, 12.3% of respondents used less than 1 g/week, 20.3% reported using 1-2 g/week, 31.8% reported using 3-5 g/week, 26.1% reported using 7 g/week, 6% using 28 g/week, and 3.4% using more than 28 g/week [32]. The survey was limited due to self-reported results, placebo effects, recall bias, and how efficacy was reported [32]. In this situation, the amount utilized per week ranges from 1 to 28 g [26,32]. Frequency is also a concern, as patients vary from “1-10 hits per day” or 2-3 times per day depending on the convention used [26,32].

See also  CBD Oil For Older Dogs

Finding an ideal dosage of a medical cannabis product can be difficult due to its variation among users. Every study mentioned the different doses and forms used by patients for different causes. Some studies have shown that THC +CBD had a good outcome when used as prophylactic or when given in acute attack [20]. Combination studies of Amitriptyline and THC or Amitriptyline and CBD should be done in order to find the improvement in efficacy and dose reduction of Amitriptyline for abortive as well as curative treatment. Also, more research should aim in doing controlled studies about the route and dose of THC/CBD for migraine and headache patients.

As with all research, limitations exist that prevent a quality analysis. This literature review is limited by the number of articles that were selected to begin. The use of cannabis with other recreational drugs was not excluded from the studies. Also, the selected studies had their own limitations as the articles were surveys collected, online surveys, a small sample size, and very few controlled trials. The lack of standardization may affect the quality of our results. Despite the limitations of the above studies, medical cannabis is an effective alternative treatment for managing headache and migraine symptoms. Our review article shows that cannabis use is picking up in patients with chronic pain and can be expected to continue to rise upwards in the face of increasing societal awareness and availability of legal cannabis [33]. Careful questioning and discussing with the patients about the use of marijuana, its risks, and benefits should be documented and researched. More information about the doses, frequency, methods, and forms of marijuana consumed, as well as alcohol use, illicit drug, and prescription drug use, should be explored to form the definitive treatment goal for migraine and headache patients [34].

Conclusions

The review article shows encouraging data on medicinal cannabis’s therapeutic effects on alleviating migraines in all of the studies reviewed. Beneficial long-term and short-term effects of medicinal cannabis were reported. It was effective in decreasing daily analgesic intake, dependence, and level of pain intensity. Some patients experienced a prolonged and persistent improvement in their health and well-being (both physically and mentally) after long-term use of medicinal cannabis. Overall, patients reported more positive effects rather than adverse effects with medical cannabis use. Chronic pain and mental health are the two reasons where medical cannabis is used often. It is found that some medical providers are hesitant to recommend medical cannabis due to a lack of current evidence, medical professional training, and a lack of uniform medical cannabis use guidelines. The therapeutic benefits of cannabis should be studied widely with intensive research trials supervised and controlled by authorities for safety and quality effectiveness. Further research should be performed once cannabis becomes legalized to determine a favorable delivery method, dose, and strain for migraine and chronic headache management and possible long-term effects of medical cannabis use. While medical cannabis is in a “disorganized realm” at the moment due to a lack of substantial research and medical provider education and patient education, this field is evolving and expanding to provide up-to-date research for both patient and doctor.

Acknowledgments

The authors would like to acknowledge Dr. Marcos A. Sanchez-Gonzalez for his constant support throughout the course of the manuscript. In addition, the authors appreciate the support of Dr. Marie-Pierre Belizaire, Dr. Madiha Zaidi, Prathima Guntipalli, and Rahima Taugir. Finally, the authors would like to thank the reviewers for their constructive feedback.

Notes

The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research and reference purposes. Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus.

Footnotes

The authors have declared that no competing interests exist.

References

1. Medical reasons for marijuana use, forms of use, and patient perception of physician attitudes among the US population. Azcarate PM, Zhang AJ, Keyhani S, Steigerwald S, Ishida JH, Cohen BE. J Gen Intern Med. 2020; 35 :1979–1986. [PMC free article] [PubMed] [Google Scholar]

2. Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and cannabis science. Baron EP. https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.13345. Headache. 2018; 58 :1139–1186. [PubMed] [Google Scholar]

3. Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells. Giudice ED, Rinaldi L, Passarotto M, et al. https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.1206738. J Leukoc Biol. 2007; 81 :1512–1522. [PubMed] [Google Scholar]

4. Cannabis and neuropsychiatric disorders: an updated review. Chayasirisobhon S. https://pubmed.ncbi.nlm.nih.gov/31867704/ Acta Neurol Taiwan. 2019; 28(2) :27–39. [PubMed] [Google Scholar]

5. Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Russo EB. https://pubmed.ncbi.nlm.nih.gov/18404144/ Neuro Endocrinol Lett. 2008; 29 :192–200. [PubMed] [Google Scholar]

7. Endocannabinoid system and migraine pain: an update. Greco R, Demartini C, Zanaboni AM, Piomelli D, Tassorelli C. Front Neurosci. 2018; 12 :172. [PMC free article] [PubMed] [Google Scholar]

8. Practical considerations of hypotheses and evidence in cannabis pharmacotherapy: refining expectations of clinical endocannabinoid deficiency. Cogan PS. J Diet Suppl. 2020; 17 :608–624. [PubMed] [Google Scholar]

10. Cannabis guidelines. Kennedy Sheldon L. https://pubmed.ncbi.nlm.nih.gov/28738036/ Clin J Oncol Nurs. 2017; 21 :409. [PubMed] [Google Scholar]

11. Practical strategies using medical cannabis to reduce harms associated with long term opioid use in chronic pain. MacCallum CA, Eadie L, Barr AM, Boivin M, Lu S. Front Pharmacol. 2021; 12 :633168. [PMC free article] [PubMed] [Google Scholar]

12. Compassionate Medical Cannabis Act of 2014. [Aug;2021 ];Florida senate. (2014. https://www.flsenate.gov/Session/Bill/2014/1030 Compassionate Medical Cannabis Act of. 2014

13. Cannabinoids in health and disease. Kogan NM, Mechoulam R. Dialogues Clin Neurosci. 2007; 9 :413–430. [PMC free article] [PubMed] [Google Scholar]

14. Medical cannabis: do the benefits outweigh the risks? Gupta S, Phalen T, Gupta S. https://www.mdedge.com/psychiatry/article/155158/medical-marijuana-do-benefits-outweigh-risks Current Psychiatry. 2018; 17 :34–41. [Google Scholar]

15. Weighing the benefits and risks of medical marijuana use: a brief review. [Oct;2020 ];Karst A. http://10.3390/pharmacy6040128 Pharmacy (Basel) 2018 6 :128. [PMC free article] [PubMed] [Google Scholar]

16. Cluster attacks responsive to recreational cannabis and dronabinol. Robbins MS, Tarshish S, Solomon S, Grosberg BM. Headache. 2009; 49 :914–916. [PubMed] [Google Scholar]

17. Migraine frequency decrease following prolonged medical cannabis treatment: a cross-sectional study. Aviram J, Vysotski Y, Berman P, Lewitus GM, Eisenberg E, Meiri D. https://www.mdpi.com/2076-3425/10/6/360 Brain Sci. 2020; 10 :360. [PMC free article] [PubMed] [Google Scholar]

18. Psychoactive substances as a last resort – a qualitative study of self-treatment of migraine and cluster headaches. Andersson M, Persson M, Kjellgren A. https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-017-0186-6. Harm Reduct J. 2017; 14 :60. [PMC free article] [PubMed] [Google Scholar]

19. Short- and long-term effects of cannabis on headache and migraine. Cuttler C, Spradlin A, Cleveland MJ, Craft RM. https://www.sciencedirect.com/science/article/pii/S152659001930848X. J Pain. 2020; 21 :722–730. [PubMed] [Google Scholar]

20. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. Baron EP, Lucas P, Eades J, Hogue O. J Headache Pain. 2018; 19 :37. [PMC free article] [PubMed] [Google Scholar]

21. Effects of medical cannabis on migraine headache frequency in an adult population. Rhyne DN, Anderson SL, Gedde M, Borgelt LM. Pharmacotherapy. 2016; 36 :505–510. [PubMed] [Google Scholar]

22. Use of cannabis among 139 cluster headache sufferers. Leroux E, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A. Cephalalgia. 2013; 33 :208–213. [PubMed] [Google Scholar]

23. Medical efficacy of cannabinoids and cannabis: a comprehensive review of the literature. Bagshaw SM, Hagen NA. https://journals.sagepub.com/doi/abs/10.1177/082585970201800207. J Palliat Care. 2002; 18 :111–122. [PubMed] [Google Scholar]

24. Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial. Pini LA, Guerzoni S, Cainazzo MM, et al. J Headache Pain. 2012; 13 :677–684. [PMC free article] [PubMed] [Google Scholar]

25. Cannabis for migraine treatment: the once and future prescription? An historical and scientific review. Russo E. Pain. 1998; 76 :3–8. [PubMed] [Google Scholar]

26. Who is using cannabis as a medicine and why: an exploratory study. Ogborne AC, Smart RG, Weber T, Birchmore-Timney C. J Psychoactive Drugs. 2000; 32 :435–443. [PubMed] [Google Scholar]

27. Medical cannabis use among adults in the Southeastern United States. Salazar CA, Tomko RL, Akbar SA, Squeglia LM, McClure EA. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388700/ Cannabis. 2019; 2 :53–65. [PMC free article] [PubMed] [Google Scholar]

28. Alleviative effects of Cannabis flower on migraine and headache. Stith SS, Diviant JP, Brockelman F, Keeling K, Hall B, Lucern S, Vigil JM. https://www.sciencedirect.com/science/article/abs/pii/S2095496420300741. J Integr Med. 2020; 18 :416–424. [PubMed] [Google Scholar]

30. Cannabis use preferences and decision-making among a cross-sectional cohort of medical cannabis patients with chronic pain. Boehnke KF, Scott JR, Litinas E, Sisley S, Clauw DJ, Goesling J, Williams DA. J Pain. 2019; 20 :1362–1372. [PubMed] [Google Scholar]

31. Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep. Piper BJ, DeKeuster RM, Beals ML, et al. J Psychopharmacol. 2017; 31 :569–575. [PubMed] [Google Scholar]

32. A cross-sectional survey of medical cannabis users: patterns of use and perceived efficacy. Sexton M, Cuttler C, Finnell JS, Mischley LK. Cannabis Cannabinoid Res. 2016; 1 :131–138. [PMC free article] [PubMed] [Google Scholar]

33. Cannabis use in hospitalized patients with chronic pain. Orhurhu V, Urits I, Olusunmade M, et al. Adv Ther. 2020; 37 :3571–3583. [PMC free article] [PubMed] [Google Scholar]

34. An analysis of applicants presenting to a medical marijuana specialty practice in California. Nunberg H, Kilmer B, Pacula RL, Burgdorf J. J Drug Policy Anal. 2011; 4 [PMC free article] [PubMed] [Google Scholar]

The Ultimate Guide for Using CBD for Headaches

CBD is a popular option for people looking for natural ways to treat pain and discomfort, including chronic headaches and migraines. When creating a CBD oil for headaches treatment plan, you’ll want to follow the steps outlined below:

How to Use CBD for Headaches

  1. Decide on Topical or Oral CBD
  2. Figure Out Dosage
  3. Rest and Evaluate
See also  Does CBD Oil Make Urine Smell

CBD is a medicinal cannabis compound extracted from hemp plants (genus cannabis) with minimal or no THC content. It works in the body by regulating and protecting the endocannabinoid system, which influences inflammation, pain, sleep, and more.

Studies have shown that the therapeutic benefits of CBD for headaches could be more than previously thought, as it may help to reduce the pain associated with headache and migraine conditions. In a recent medical study , those who received CBD reported a significant reduction in the amount of headache pain than those who were not given CBD.

Can CBD Help with Headaches?

Because a migraine headache is so common and debilitating, there have been many clinical trial research studies performed to find an effective treatment for reducing the incidence of migraines and lessen the migraine pain. One therapy that’s becoming increasingly popular is using CBD for headaches.

A study on the use of medical marijuana for a chronic migraine was published in the journal Pharmacotherapy in 2016. Researchers discovered that 39.7 percent of the 48 persons polled said they had fewer migraine bouts overall. The research reported that the frequency of chronic migraines in a group of medicinal marijuana users was reduced from about 10 per month to only around four per month. And according to research presented at the European Academy of Neurology’s Congress in 2017, CBD may reduce migraines and relieve the agony of migraine headaches, according to research

How Does CBD Oil Help with Headaches?

A tension headache is a common condition that causes severe pain behind the eyes, around the temples, or in the back of the head. It can be triggered by anything from stress and lack of sleep to sinus problems and menstruation. The pain can vary from mild to severe, and sometimes it’s hard to tell what’s causing it in the first place. CBD is thought to lessen the nerve pain by attaching to glycine receptors in the brain, which control how quickly nerve signals flow between nerve cells.

The benefits of CBD for a severe headache are many, and range from mild to long-term relief. Individuals with a history of addiction to other substances may also take advantage of CBD for a headache as it’s not addictive, making it a safe option to consider if you need to stop taking an over-the-counter or prescription medication for pain.

There have been studies of the dulling effects CBD has on pain. By interrupting the messages from the brain to the body, the user doesn’t feel the pain as an acute migraine. Not surprisingly, roughly four out of 10 men and women who use CBD products, say they use them for migraine relief.

CBD oil may also help with long-term relief by reducing migraine symptoms that have been long-term triggers for the individual. For example, people who regularly experience chronic pain tend to have a heightened sense of anxiety; this is not only unpleasant, but it can take a serious toll on overall mental health.

CBD oil has been shown to be an effective anxiety treatment. This is because CBD may help balance out the brain’s endocannabinoid system, producing naturally occurring chemicals, like anandamide. CBD oil may also positively affect certain types of headaches, such as a chronic migraine or cluster headache.

Is CBD Safe for Headache Use?

CBD, unlike THC, doesn’t produce a euphoric high or psychoactive effect, making it less contentious and safer for medical use. CBD oil has proven to be useful in treating a variety of conditions; detailed in a number of health studies.

CBD is a great, natural alternative to traditional medication because it has minimal side effects. If you’re uncomfortable with the idea of using marijuana, CBD oil is a great option because it can give you similar migraine relief without the psychoactive high. It’s available in various strengths from different CBD brands or health stores.

CBD oil products made from CBD have become increasingly popular in the medical market because of their functional wellness benefits. CBD has a calming effect on the nervous system, and some users of CBD oil have reported benefits like relief from chronic headaches.

Just like any other type of natural medication, CBD oil does not have to be taken in large quantities to be effective. You need just the right amount of CBD in your system for the proper dose to work.

How to Use CBD for Headaches

1. Decide On Topical or Oral CBD Usage

Oral applications and topicals are the two of the most popular ways people take CBD. According to the National Institute on Drug Abuse (NIDA), people can take CBD by ingesting it in beverages or edible CBD products, like CBD gummies , tinctures , or soft gel capsules . There are also topicals you can apply directly to your skin, such as salves and lotions.

CBD Topicals

Topical CBD creams are one of the most popular ways to enjoy the therapeutic effects of CBD. After you apply the lotion or salve, your body absorbs the CBD oil through its skin.

CBD topicals deliver the primary benefits of CBD to your body through two main mechanisms:

  1. Cannabinoids bind with receptors near pain pathways and block out pain signals.
  2. CBD works on many levels, including reducing swelling and inflammation.

When applied topically, substances that interact with the CB2 receptors in our bodies can help relieve pain, which is why many people often use topical CBD creams for arthritis pain, soreness, or other chronic conditions.

When you apply CBD topicals directly to the skin, it can help reduce swelling and other migraine symptoms associated with inflammation.

Oral CBD Usage

CBD can be prescribed by a doctor in pill form or taken through a tincture oil. Taking CBD orally implies consuming CBD through the mouth. There are two ways to orally ingest CBD for headaches:

Sublingually

This approach, often known as “under-the-tongue,” involves placing droplets of CBD oil tinctures beneath your tongue and holding them there for 30 to 60 seconds before swallowing. CBD is absorbed through the capillaries in your mouth, entering the circulation and finally reaching the ECS’s cannabinoid receptor.

Compared to other CBD applications, this CBD consumption technique offers one of the greatest bioavailability percentages. Because CBD molecules are delivered directly into the bloodstream through the mouth’s mucous membranes, they avoid being processed through the first-pass metabolism.

Ingestion

Directly swallowing CBD in the form of a pill, candy, soft gel, or other edible ways is referred to as ingesting CBD. When you consume CBD, the molecules must first go through your digestive system and make their way to your liver, where they are first broken down; this is referred to as the first-pass metabolism.

The remaining chemicals are then delivered to the bloodstream once the liver has metabolized the CBD. Therefore, CBD has slightly lower bioavailability when consumed; digestive enzymes break it down into useless components before it reaches the bloodstream. Ingested CBD, on the other hand, appears to still have a long-lasting compared with any other application route.

Which Type of CBD Oil Should I Use for my Headache?

If your migraine pain or discomfort is localized to the temples or the base of your neck, a topical CBD product could be very effective, but if you have whole-body pain or the affected pain area is covered by your head hair, an oral CBD product may be a better option. Don’t be afraid to try both, though, and decide for yourself which one works best for your headache pain.

2. Figure Out Dosage

Your optimal dosage amount of CBD oil will depend on a variety of factors, including weight and metabolism. It is always recommended to start low and go slow when using new medications or supplements. Everyone has an individual tolerance level, which is why the recommended CBD Dosage may range from person to person.

The most common CBD oil dosage is between 25mg to 50mg per day. The amount you take can vary based on the severity of your headache and the length of time you’ve been experiencing migraine symptoms. Keep in mind that you should take it consistently to be effective if you are taking CBD oil for chronic pain.

The effects of CBD may also depend on what type of CBD you are using. For example, if you start with a product at a lower concentration, such as 15 mg per day for three days, and then increase to 30 mg per day for another week or so before increasing again, this will help your body adjust to the effects.

3. Rest and Evaluate

Now that you’ve determined which CBD product to use and how much to consume, it’s time to sit back, rest, and evaluate.

If the CBD treatment is effective, your headache pain will begin to subside and you’ll start feeling more relaxed. If you can, take a nap—the CBD will help you sleep, and it’s a great way to let your brain rest as much as possible.

If you don’t feel much of anything after a couple hours, you may need to try a stronger dose or different consumption method. You may also consider rubbing CBD salve or CBD balm on your temples and neck, which can help relax the muscles and give you relief.

Are there any CBD side effects to watch out for?

CBD has very minimal side effects, but there are a few you might experience if you consume too much or are particularly sensitive to cannabinoids.

The most likely side effect you’ll experience is feelings of sleepiness or lethargy. However, CBD can also cause nausea and diarrhea. Because nausea and diarrhea are common side effects of many other drugs, patients may consider consulting with their doctor if they experience any of them.

You can also minimize side effects by drinking adequate water, eating enough protein, and getting sufficient sleep. Patients who suffer from frequent migraine attacks might need to take more than one dose per day and receive continuous therapy.

Where to Buy CBD Products for Headaches

More and more people are turning to CBD oil to manage chronic headaches and migraines, and for good reason: CBD is an effective treatment for headaches due to its anti-inflammatory, pain-relieving properties. It’s also natural, making it a great alternative to prescription medications.

If you’re ready to try CBD oil for headaches, shop FarmerandChemist.com ’s wide selection of CBD products. We carry only the highest-quality, premium CBD products, and have a team of pharmacists and pharmacy technicians ready to answer any questions you may have about using CBD to treat headaches or migraines.