CBD Oil For Lichen Planus

Ever since my LP has started I've dealt with muscle stiffness and spasm. I 've read that CBD helps with skin… The skin is the largest organ in the human body. One of its principal functions is to protect the body against external agents and it is the first defensive barrier of the innate immune system. Other important functions of the skin include controlling body temperature, maintaining the hydro-electrolytic balance and perceiving painful or pleasurable stimuli. Any alteration in In this article, we explain all you need to know about CBD oil for lichen planus, including how it works and the best products.

Has anyone tried CBD lotion/oil for thier LP?

Ever since my LP has started I’ve dealt with muscle stiffness and spasm. I ‘ve read that CBD helps with skin conditions and also muscle spasms so I tried it, and let me just say. I’m impressed with the results. My spasms has stopped and my scares are clearing up. I was just wondering if anyone else has tried CBD and what their results were,

2 likes, 38 replies

38 Replies

mary_pooh garbear

Posted 4 years ago

How exciting ! My daughter kept telling me to try that so I’m going to get some can you tell me how much you dab on and can you use it for oral LP ? X hope it carries on working how long have you been using it ? Xx

garbear mary_pooh

Posted 4 years ago

Hello pooh, I’ve been symptom free for about 1 1/2 years but the cbd was not responsible for my remission. I have to contribute my remission to probiotics. I use a lotion with 25 milligrams of cbd in a 8oz bottle for the scars left behind and it has helped tremendously. In the time it took me to use the 8oz bottle, which was about two months. Hope it can help you too.

garbear mary_pooh

Posted 4 years ago

I’m glad to hear this pooh. I only hope others will come a cross this post. CBD has so much potential to be a benefit to millions of people. Spread the word and God bless

mary_pooh garbear

Posted 4 years ago

Thankyou yes I’m spreading the word ! The hospital wanted to put me on immune suppressants which I think just makes you feel worse I’m determined to fight this as naturally as I can !! I’m positive for Epstein Barr virus which I believe is causing LP I’ve googled loads !! God bless you and all sufferers xx

garbear mary_pooh

Posted 4 years ago

I was on immune suppressant for a while to, small doses tho. It’s not a bad idea especially if your breakouts are bad. It will help get it under control and then take a probiotic to rebuild your immune system. That’s what I did for my skin LP

mary_pooh garbear

Posted 4 years ago

Will see if CBD works first !! Got CT scan tomorrow they found chronic stomach ulcer and errosion plus hiatus hernia took ten biopsies so now investigating more ! I’m falling to bits . Xx I keep smiling tho and sending out positive vibes !!

anne_j63826 mary_pooh

Posted 4 years ago

Hi I am a new cannabis user (3 drops 3 times a day and increasing, mostly for back pain). However I have suffered from oral LP since 2015. After a long remission, it returned after my immune cancer therapy last September, and nothing helped. Since starting cannabis oil I have experienced a lessening of the symptoms and even of the dry mouth I had at the beginning. Today I am eating almost normally – thanks to cannabis? This demonstrates that even taking it by mouth is effective (I use a steroid gel on the ulcers in the mouth).

cleo15 garbear

Posted 4 years ago

May I ask you what probiotics you take? I was told that most of them don’t get past the digestive system.

anne_j63826 cleo15

Posted 4 years ago

None. only vitamins and food additives (glucosamine sulphate) and magnesium. Meanwhile the situation in my mouth has worsened again, but as I still not up to full dose, maybe there is hope yet!

mary_pooh anne_j63826

Posted 4 years ago

I took the oil for 6 weeks noticed an improvement then stopped for two weeks and mouth went red raw very quickly so I’m back on it I’m sure it helps. It does seem to give me more energy too but I think it gives me headaches !? X

anne_j63826 mary_pooh

Posted 4 years ago

Maybe I should concentrate on keeping the solution on the ulcers instead of immediately swallowing it

mary_pooh anne_j63826

Posted 4 years ago

Mine are oil capsules so I swallow them but if yours is oil drops it’s best to put them under your tongue as that way it goes straight into your bloodstream xx if you’re in UK I can let you know company I get mine from !? X

garbear cleo15

Posted 4 years ago

Hello Cleo15, I take two different probiotics both are store brand, doesn’t matter which brands long as it is one’s with 5-10 billion live active cultures as far as type of organisms, the more diverse the better, I take mine with food as it helps absorption of the probiotics, one at breakfast and one at dinner, sometimes I’ll take three a day. Be sure to start with one a day and work your way up to more gradually or you’ll regret it.

anne_j63826 mary_pooh

Posted 4 years ago

ufoundmee mary_pooh

Posted 3 years ago

Mary I’m very interested. Has this worked for your nails? are they returning to more normal? If so can you tel me what CBD stands for please? I hope you still get these messages as I’m desperate to find something to help my daughter’s lichen planus.

Cannabinoids and Inflammatory Skin Diseases

Doctor in Medicine and Surgery, Professor of Immunology at the Department of Cellular Biology, Physiology and Immunology of the University of Cordoba and Director of the Inflammation and Cancer Research Group at the Maimónides Institute of Biomedical Research in Cordoba. Dr Muñoz Blanco’s research centres on the study of cannabinoids in inflammatory diseases and the development of new semi-synthetic cannabinoids. In 2003, he founded VivaCell Biotechnology España, which develops new pharmaceuticals based on non-psychotropic cannabinoids.

The skin is the largest organ in the human body. One of its principal functions is to protect the body against external agents and it is the first defensive barrier of the innate immune system. Other important functions of the skin include controlling body temperature, maintaining the hydro-electrolytic balance and perceiving painful or pleasurable stimuli. Any alteration in the functioning or appearance of the skin can have important consequences for our physical and mental health. Many of the problems that present in the skin are limited to it. In some cases, however, the skin can reveal a disorder affecting the entire body.

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Development of Pharmaceuticals in Dermatology

Nearly 37% of primary health care patients have some acute or chronic skin disease and it is surprising how few new pharmaceuticals are being developed to treat these conditions –particularly those most commonly treated by dermatologists and non-dermatologists– when compared to other pathologies. One important reason why few pharmaceutical companies are developing drugs for skin diseases is that the economic return on such drugs (especially topical skin products) is relatively small when compared to the market for pharmaceuticals for other conditions (e.g. cardiovascular diseases) (Eaglstein and Corcoran, 2011).

Another factor limiting the development of pharmaceuticals based on natural products –including preparations of Cannabis sativa– is the fact that in most cases it is not possible to establish adequate protection for intellectual property of the drug, an essential inventive to investment in the development of new pharmaceuticals for any application. It is therefore hardly surprising that the great majority of skin diseases, especially inflammatory diseases, are treated with over-the-counter health-care (para-pharmaceutical) products whose effectiveness, in most cases, is not proven.

Cannabinoids in Dermatology

The topical use of Cannabis sativa L dates back to ancient China, where cannabis preparations were used externally to treat skin rashes, ulcers, wounds and hair loss. There is also archaeological evidence suggesting that topical cannabis preparations were used by the ancient Egyptians to treat eye conditions and also in bandages for wounds. Cannabis leaves were used in medieval Arab medicine to treat skin diseases such as pityriasis and lichen planus. More recently, in the early twentieth century, before prohibition, tinctures of cannabis were commonly sold in pharmacies. Among other applications, they were used to treat calluses, irritable bladder, menstrual pains and as an aid for quitting opium addiction.

The skin possesses all the elements of the endocannabinoid system, i.e., endocannabinoid compounds (AEA and 2-AG), metabotropic (CB1R and CB2R) and ionotropic (TRPV-1) receptors of cannabinoids and the enzymes involved in the synthesis and metabolism of endocannabinoids (e.g. FAAH and MAGL). The various elements in the endocannabinoid system are involved in key mechanisms of skin regulation, such as control of growth of the epidermis and skin annexes, cell survival, immune and inflammatory responses, the transmission of sensory stimuli to the central nervous system (pain, itching) and the synthesis of lipids, among other activities.

Despite this long history of topical use of cannabis and advances in our understanding of the endocannabinoid system of the skin, research into the use of cannabinoids for skin pathologies is one of the youngest fields of research in this area and clinical data on the use of cannabis in dermatological practice remain extremely limited. Nonetheless, there is increasing evidence of the potential of cannabinoids for the treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis and for the treatment of auto-immune diseases such as scleroderma, characterised by inflammation and fibrosis.

Psoriasis

Psoriasis is one of the most common chronic inflammatory skin diseases. It is characterised by hyper-proliferation and shedding of keratinocytes, resulting from infiltration of T-cells and neutrophils and activation of dendritic cells and macrophages. Although the pathogenesis of psoriasis is not fully understood, there is solid evidence to suggest that deregulation of the immune cells in the skin, in particular Th1 and Th17 cells, plays a critical role in the development of psoriasis.

Although there is at present only anecdotal evidence on the use of Cannabis sativa L preparations for topical use in psoriasis, the therapeutic possibilities of cannabinoids acting through CB2R and through mechanisms that are independent of classical cannabinoid receptors are very broad given their role in the regulation of Th1 and Th17 lymphocytes (Derakhshan and Kazemi, 2016). It has also been seen that some phytocannabinoids inhibit the proliferation of keratinocytes through non CB1R and CB2R paths (Wilkinson and Williamson, 2007).

Atopic dermatitis

Atopic dermatitis (AD) is the most frequent chronic inflammatory disease of the skin. Initiation and progression of the disease are induced by interactions of genetic, environmental and immunological factors. The clinical characteristics of AD include dryness of the skin through loss of the epidermal barrier, erythema, exudation, scabs and lichenification. Moreover AD is characterised by intense itching which leads to frequent scratching and infection by staphylococcus. There is no cure for AD and the main goals of treatment are to reduce the symptoms (itching and dermatitis), prevent exacerbations and minimise the risk of skin infection. Standard forms of treatment for managing AD patients centre on the use of anti-inflammatory topical preparations with corticoids and hydration of the skin, but in serious cases, patients may require systemic treatment with powerful immunosuppressives –such as cyclosporin A or tacrolimus– and antibiotics to prevent infection by staphylococcus-type bacteria.

Numerous para-pharmaceutical preparations are now available based on oil from Cannabis sativa L seeds, especially hemp, for the treatment of AD. However, despite the misleading advertising often used to market such products, hemp seed oil does not contain cannabinoids or other bioactive phenolic compounds, and its therapeutic effect goes no further than any other preparation containing polyunsaturated fatty acids and favouring skin hydration.

However, to judge from pre-clinical studies, cannabinoids also have great potential for therapeutic management of AD (Ong PY, 2009; Wollenberg and cols, 2014). In this regard, selective CB1R agonists inhibit the activation of mastocytes and the release of histamine. Moreover, topical application of anandamide analogs has been shown to reduce skin inflammation in animal models of AD (Kim et al., 2015). Other authors have suggested that CB1R expression in keratinocytes plays a relevant role in maintaining the epidermal barrier (Gaffal et al., 2014). Finally it has also been described that the release of histamine from CB2R inhibits the inflammatory skin reaction mediated by IgE and intense spontaneous pruritus in AD (Maekawa et al., 2006).

The antibacterial action of Cannabis sativa preparations and phytocannabinoids has been well known for decades, although only more recently has the antibacterial activity of cannabinoids THC, CBD, CBG and their precursors (acid forms) against methicillin-resistant staphylococcus been demonstrated (Appendino et al., 2008).

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Nearly 100 cannabinoids have been identified in the plant, together with a large number of other bioactive compounds, such as phenolics and terpenes, which also have important antioxidant and anti-inflammatory activities (Hanuš et al., 2016; Russo, 2011). The cannabinoids and other types of compound are thought to have interacting synergic effects. This would explain why in some in vitro studies, better results have been obtained with extracts from the plant than with pure isolated compounds. Although the content of cannabinoids and other types of compound varies depending on the variety of plant, cannabinoids can be said to have huge potential for treating AD, given their anti-inflammatory and antibacterial properties.

Cannabinoids and fibrotic skin diseases

Systemic scleroderma (or sclerosis) (SSc) is a rare autoimmune disease that has three main characteristics: dysfunction of fibroblasts, leading to an increase in the deposition of proteins from the extracellular matrix, vasculopathy of small vessels resulting in tissue hypoxia and an immune response with production of proinflammatory cytokines and autoantibodies. SSc is characterised by progressive thickening and fibrosis of the skin, secondary to excessive accumulation of collagen, which can be limited to the skin (localised –or limited– cutaneous SSc) or extend to internal bodies (diffuse SSc). SSc begins with a microvascular injury and inflammation. This is followed by fibroblast activation, a key event in the development of fibrosis.

Recent evidence shows that genetic and pharmacological manipulation of the endocannabinoid system modulates the fibrotic response. CB1 and CB2 receptors, too, have shown different patterns in experimental models of dermal fibrosis. Blockage of CB1R prevents activation of fibroblasts and has a powerful antifibrotic effect (Marquart et al., 2010). The role of CB1R as a profibrotic receptor has also been confirmed in knock-out mice for FAAH, in which high levels of endocannabinoids can induce fibrosis through a CB1R-dependent path. On the other hand, activation of CB2R prevents cutaneous fibrosis and the infiltration of tissue leukocytes in models of experimental dermal fibrosis (Akhmetshina et al., 2009). As a result, JWH-133, a synthetic agonist of CB2R abrogates experimental dermal fibrosis in mouse models. This concurs with the fact that the CB2R knock-out mice are more susceptible to the development of fibrosis (Balistreri et al., 2011). It has also been demonstrated that PPARγ agonists inhibit the profibrotic response by inhibiting the TGFβ signalling path. It has also been demonstrated that dual agonists of PPARγ/CB2R show a powerful anti-inflammatory and anti-fibrotic activity in experimental models of SSc (Del Río et al., 2016).

References:

1. Akhmetshina, A. Dees C, Busch N, Beer J, Sarter K y cols. The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis. Arthritis and rheumatism 2009; 60:1129-1136.
2. Appendino G, Gibbons S, Giana A, Pagani A, y cols. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. J Nat Prod. 2008; 71:1427-30.
3. Balistreri E, Garcia-Gonzalez E, Selvi E, Akhmetshina A, y cols. The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model. Annals of the rheumatic diseases 2011; 70: 695-699.
4. Derakhshan N, Kazemi M. Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review. Curr Clin Pharmacol. 2016; 11:146-7.
5. del Río C, Navarrete C, Collado JA, Bellido ML y cols. The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γand CB2 pathways. Sci Rep. 2016:18; 6:21703
6. Di Marzo V, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004; 3:771–784.
7. Eaglstein WH, Corcoran G. New drugs and new molecular entities in dermatology. Arch Dermatol. 2011 May;147(5):568-72.
8. Gaffal E, Glodde N, Jakobs M, Bald T y cols. Cannabinoid 1 receptors in keratinocytes attenuate fluorescein isothiocyanate-induced mouse atopic-like dermatitis. Exp Dermatol. 2014; 23:401-6.
9. Hanuš LO, Meyer SM, Muñoz E, Taglialatela-Scafati O, Appendino G. Phytocannabinoids: a unified critical inventory. Nat Prod Rep. 2016. 33:1357-1392.
10. Iannotti FA, Hill CL, Leo A, Alhusaini A y cols. Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem Neurosci. 2014; 19:1131-41.
11. Kim HJ, Kim B, Park BM, Jeon JE y cols. Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone-induced atopic dermatitis model. Int J Dermatol. 2015; 54:e401-8.
12. Maekawa T, Nojima H, Kuraishi Y, Aisaka K. The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol. 2006; 542:179-83.
13. Marquart S, Zerr P, Akhmetshina A, Palumbo K y cols. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum. 2010; 62:3467-76.
14. Ong PY. Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009; 14:165-79.
15. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011. 163:1344-64.
16. Sido JM, Nagarkatti PS, Nagarkatti M. Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease. Int Rev Immunol. 2015; 34:403-14.
17. Turcotte C, Blanchet MR, Laviolette M, Flamand N. The CB(2) receptor and its role as a regulator of inflammation. Cell Mol Life Sci. 2016; 73: 4449-4470.
18. Wilkinson JD, Williamson EM. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci. 2007; 45:87-92.
19. Wollenberg A, Seba A, Antal AS. Immunological and molecular targets of atopic dermatitis treatment. Br J Dermatol. 2014; 170 Suppl 1:7-11.

Can CBD Oil Help Lichen Planus? [All You Need to Know]

Lichen planus is a skin condition that can affect the body, scalp, genitals, or mouth. It can cause sufferers to experience extreme discomfort, sometimes even making it challenging to eat or drink.

Nowadays, more people are becoming aware of CBD’s potential to relieve skin disorders like eczema and acne. Therefore, many are wondering whether this cannabinoid could help to ease lichen planus symptoms too.

So, is CBD oil good for lichen planus, or is this just wishful thinking? Here’s all you need to know.

What Is Lichen Planus?

Lichen planus causes clusters of raised lesions, known as papules, on the skin. It can affect the body (most commonly the wrists, ankles, and lower back), the scalp, or the mucous membranes. The latter includes the inside of the mouth and the genitals.

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The condition usually resolves by itself within 1–2 years, although it can recur and may also leave behind scarring. It is most common in adults aged between 30 and 60 and affects slightly more women than men.

Is it effective? …

Lichen Planus Symptoms

The papules that lichen planus causes can vary in appearance depending upon where they occur.

On the body, they tend to be:

These lesions are often very itchy, although, in some cases, they may not itch at all. In the mouth, lichen planus appears as white patches on the tongue, gums, and inside the cheeks. It can cause burning sensations inside the mouth, which eating or drinking may aggravate.

On the genitals, the condition can cause either sore, red patches on the vulva, or ring-shaped patches on the penis. When it occurs on the scalp, lichen planus can cause bald patches, alongside sore or itchy lesions. Lichen planus may also affect the nails, causing them to become rough, thin, and grooved.

What Causes Lichen Planus?

It is unclear why some people develop lichen planus. Most experts agree that it usually stems from an allergic or immune reaction to an irritant.

It appears that, in some people, exposure to certain chemicals, including metals, dyes, and medications, can cause an inflammatory response. Viruses like hepatitis C may also trigger lichen planus in some instances.

What Is the Best Treatment for Lichen Planus?

The most common treatments for lichen planus include corticosteroid creams or ointments to reduce inflammation and itching.

If these are ineffective, doctors may prescribe corticosteroid injections or tablets. In severe cases, drugs to suppress the immune system may be necessary. Other options include light therapy or mouthwashes for oral lichen planus.

Making some lifestyle adjustments may also help, including:

  • Washing with plain, warm water and avoiding scented soap or body wash
  • Washing the hair over a sink so that shampoo does not drip onto the skin
  • Using an emollient cream to moisturize the skin regularly
  • Avoiding tight-fitting clothing
  • Brushing the teeth carefully
  • For oral lichen planus, avoiding alcohol, alcohol-containing mouthwashes, and salty, spicy, or acidic food and drink.

Now that CBD oil is becoming more widely available, some people are wondering whether it could help lichen planus. Let’s take a look.

Is CBD Oil Good for Lichen Planus?

Cannabidiol (CBD) is a type of chemical known as a cannabinoid. It is one of the many active components that hemp and certain cannabis strains produce. It has become increasingly mainstream in recent years due to its potential benefits for various conditions, including some skin disorders.

Unfortunately, there is currently no research on CBD oil for lichen planus, specifically. However, a 2019 review for Molecules suggests that CBD could influence skin health in several ways. It works by altering the body’s endocannabinoid system (ECS), which is present in several different types of skin cells.

This system helps to maintain a state of balance by regulating the rate at which skin cells grow, develop, and die. Therefore, it seems that ECS dysfunction could play a crucial role in many different skin conditions.

Scientists have become especially focused on the role of the ECS in inflammatory skin diseases. It seems that our body’s natural cannabinoid compounds can reduce inflammation by regulating immune system activity.

This is also where CBD exerts many of its beneficial effects. It helps to enhance ECS activity by slowing down the rate at which our natural cannabinoids break down.

It can also bind with cell receptors outside the ECS, including TRPV1 and PPAR-gamma receptors. Both of these play a critical role in reducing inflammation.

So, although there is no clinical evidence to support the use of CBD for lichen planus yet, it may have some effect. Furthermore, anecdotal reports from people who have tried CBD oil for lichen planus are promising.

We hope to see some more focused research emerging in the future to support these claims.

Choosing the Best CBD for Lichen Planus

Anyone wishing to try CBD oil for lichen planus will want to select the right product for their needs. Unfortunately, there is an overwhelming choice available, and it can be difficult to know where to start.

Firstly, look for a brand that provides lab reports for all of its products. Doing so will ensure that the items contain appropriate levels of CBD and other active ingredients. It also reduces the risk of contamination from chemical pesticides or fertilizers, which could irritate the skin.

Secondly, consider whether the CBD is full-spectrum, broad-spectrum, or isolate. Full-spectrum products contain a range of other cannabinoids and terpenes, many of which have additional anti-inflammatory effects.

Broad-spectrum products are similar but contain zero THC, the intoxicating compound in cannabis. As the name suggests, isolates contain CBD alone.

Next, select a product type. CBD oils are a popular choice and may be suitable for anyone suffering from oral lichen planus. They should be held in the mouth for up to 90 seconds before swallowing to increase absorption into the bloodstream.

Topical CBD products like creams or balms are another option for people with lichen planus on their skin. However, care should be taken to choose topicals without too many additional ingredients that may cause further irritation. It is sensible to try new products on a small area first and wait 24 hours to monitor any reactions.

Weighing in on CBD cream as a …

Finally, read plenty of online reviews to find a reputable brand. Many companies have jumped upon the CBD bandwagon recently, but not all of them offer high-quality goods.

Final Thoughts on CBD Oil for Lichen Planus

There is no clinical research on CBD oil for lichen planus yet, but anecdotal reports suggest that it could help. Indeed, the compound has potent anti-inflammatory properties and has proven useful for a range of other skin conditions.

Most people can take CBD oil without any serious side effects. Therefore, there is little risk in giving it a try.

That said, we recommend that anyone considering using CBD for lichen planus consults a physician first. This is especially important for anyone taking other medication, as CBD can interact with several different drugs.