CBD has proven anti-inflammatory benefits through its effects on the ECS. View the best CBD oils for inflammation. Learn more about how to figure out the right CBD dosage for your pain and other symptoms when there’s not definitive dosing information or research. Want to know how much CBD Oil you should take? Use the Veré CBD dosage chart to find the optimal CBD dosage for anxiety, inflammation, pain & more.
CBD Oil For Inflammation: What The Research Says
Inflammation is at the root of many medical conditions.
CBD oil has an impressive anti-inflammatory profile.
Here’s how it works.
In this article, you’ll learn how CBD can be used to manage a variety of inflammatory disorders.
We’ll cover how this impressive health supplement actually works, what its limitations are, and what to look for in a quality CBD oil for reducing inflammation.
Of all the health benefits of CBD, the effects on inflammation are the most impressive. There are already dozens of high-level clinical studies, and thousands of animal and in vitro studies proving the anti-inflammatory benefits of CBD and other hemp-derived phytochemicals.
Let’s dive straight in with the best CBD oils for inflammation.
MEDICALLY REVIEWED BY
Updated on October 19, 2021
Table of Contents
- General Dosage Guidelines for Inflammatory Conditions
- What Inflammatory Messengers Does CBD Interact With?
$49 – $229
Royal CBD Oil 30 mL
5 / 5
|Total CBD:||500 – 2500 mg|
|Potency:||16.6 – 83.3 mg/mL|
|Cost per mg CBD:||$0.12 – $0.18|
Best CBD Products For Inflammation
- Best CBD Oil Overall —Royal CBD Oil
- Best CBD Capsules —Gold Bee CBD Capsules
- Best CBD Oil Formula — Kiara Naturals CBD Pain Relief Tincture
- Best Nano CBD Oil — Phoria CBD Oil Nano Tincture
- Best CBD Oil in Europe — Nordic Oil Full-Spectrum CBD Oil
Summary: Can CBD Help With Inflammation?
There are dozens of chemical messengers and enzymes working together to produce inflammation in the body.
Blocking one pathway may prove useful for certain types of inflammation, but it’s not the most effective method treatment.
CBD is an excellent anti-inflammatory because it works through multiple pathways. By doing this, CBD halts the inflammatory process at several different points in the process.
Compared with common anti-inflammatory drugs such as Aspirin — which inhibits only one enzyme involved in the inflammatory process — we find CBD more effective for combating inflammation.
What Type of CBD Products Should I Use?
CBD comes in all different forms — but not all are appropriate for every condition. When it comes to inflammation specifically, there are a few types of CBD that work better than others.
Let’s cover the main types of CBD you’re likely to find and discuss their advantages and disadvantages for reducing inflammation.
1. CBD Oils & Tinctures
CBD oils are the most common form of CBD that people are using today. They allow for simple, effective dosing, and have a long shelf-life. CBD tinctures are very similar to oils, but use alcohol as the carrier instead of oils. This gives them a longer shelf-life and it makes it easier for herbalists and naturopaths to mix other anti-inflammatory herbs into the formula — however, the taste is unpleasant.
To take CBD oils and tinctures, measure out the intended dose using the supplied dropper and place under the tongue for fast onset of effects, or swallow for a slower onset of effects.
2. CBD Capsules
CBD capsules provide another popular method of consuming CBD. They take away a lot of the guesswork when it comes to dosing and make it easy to take your CBD on the go.
3. CBD Suppositories
CBD suppositories are not popular, but they’re an excellent option for addressing inflammation in the digestive tract by delivering the cannabinoids directly to the problematic site.
4. Topical CBD Products
Any inflammation involving the skin can be relieved by taking CBD internally. However, the best treatment for these conditions is usually topical. This allows the cannabinoids to concentrate effects on the inflamed local tissues.
When to Use Topical CBD:
5. CBD Edibles
Edibles — including gummies, cookies, or cooking oils — also provide useful ways of getting CBD into the body. They taste great without compromising potency. The only downside is that, with the exception of standardized gummies, it can be challenging to gauge the strength of edibles. Eating too many edibles can have other negative long-term side-effects due to the high sugar content.
Therefore, edibles are better for spot treatment rather than a daily source of CBD.
6. CBD E-Liquids and Vape Oils
Vaping CBD is the most efficient of all the dosage forms because bioavailability through the lungs is much higher than it is through the digestive tract.
However, the cost to start vaping can be steep as you’ll need to buy a vaporizer, and the duration of effects tends to be shorter than that of CBD consumed orally.
Vaping is ideal for delivering CBD to the lungs and is, therefore, a good option for lung inflammation. However, it may or may not make conditions such as asthma worse — so always use CBD vape oils with caution.
What’s The Dose of CBD Oil For Inflammation?
When it comes to inflammation, the more CBD, the better. Most of the research on using cannabinoids for inflammation indicates a dose-dependent response. This means that the more you take, the stronger the anti-inflammatory effect it produces.
Therefore, the recommended dose will vary according to the level of inflammation.
For low-grade inflammation — such as early stages of arthritis — a low strength may achieve the results you’re looking for.
To treat severe inflammation — such as inflammatory bowel disease or autoimmune diseases — you may need to opt for a medium or high strength instead.
General Dosage Guidelines for Inflammatory Conditions
|Low-Strength CBD||Moderate-Strength CBD||High-Strength CBD|
|• Early stages of arthritis
• Post-viral infection
• Low-grade traumatic injury
|• Mild allergies
• Mild depression
|• Multiple sclerosis
• Severe allergies
• Moderate depression
• Parkinson’s disease
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What Are The Side-Effects of CBD?
Although CBD is proven to be highly safe in terms of toxicity, it’s important to know about the potential side-effects. Everybody is different, and what works in one person doesn’t always work the same way in another.
Here are some of the most common side-effects of CBD:
The human body is made up of trillions of individual cells, all working together. Therefore, the cells need to be able to communicate with each other.
We use our nervous system to send messages in the form of electrical impulses to and from our brain, and we use chemical messengers to send signals around the body via the blood.
The process of inflammation relies heavily on these chemical messengers to signal the immune system and regulate blood flow to damaged areas of the body.
There are dozens of inflammatory messengers, each sending a particular type of message — some call immune cells to an area to help clean out the infection, others tell the cardiovascular system to start pooling blood in a damaged area.
Allergic reactions, for example, rely on the activation of the mast cells — which wait patiently until an allergen floats nearby. When exposed to an allergen, the cell releases a potent dose of inflammatory markers (such as histamine) that cause the cascade of inflammatory reactions that we know as an allergic reaction (for example, hives, runny nose, puffy eyes, or scratchy throat).
Here’s a map of the inflammatory process. Complicated, isn’t it?
(Source: Cavaillon et al., 2002)
You may be thinking, “I have no idea what all of this means.”
Well, you’re not alone.
Researchers are still uncovering new information about inflammation, and there are some forms of inflammation that we don’t yet understand (such as interstitial cystitis and irritable bowel syndrome, for example).
The best treatment for inflammation considers the type of inflammation.
We need to consider whether the inflammation is acute (short-lived) or chronic (long-lived). We also need to take into account whether the inflammation is caused by physical damage or an allergic or autoimmune reaction. These are essential steps to consider because each of these forms of inflammation involves different chemical messengers.
Stopping inflammation means blocking these chemical messengers.
The most important distinction to make is whether the inflammation is acute (short-term) or chronic (long-term).
1. Acute Inflammation
Acute inflammation refers to short-term inflammation — typically less than six months in duration. When we get cuts in the skin or stub our toe, we experience acute inflammation. It appears very fast and leaves once the injury has healed.
Acute inflammation can lead to chronic inflammation if the irritant persists (such as eating inflammatory foods on a regular basis).
Common causes of acute inflammation include:
The most critical messengers involved with acute inflammation are histamine, nitric oxide, and inflammatory enzymes such as COX or 5-LOX. Aspirin, for example, works by blocking the COX enzyme.
CBD inhibits the COX enzymes (both COX-1 and COX-2) responsible for producing inflammatory messengers such as leukotrienes and prostaglandins — known as key mediators in both acute and chronic inflammation .
2. Chronic Inflammation
Inflammation is categorized as chronic when symptoms continue for longer than six months.
Prolonged inflammation can cause severe damage to the systems affected.
In a nutshell, chronic inflammation works like this:
- Inflammation damages the tissue
- The tissue releases new inflammatory messengers to fix the damage
- The new inflammation causes further damage to the tissue
- The process repeats
Over long periods of time, chronic inflammation can lead to other health conditions. Prolonged inflammation may damage membranes (such as the digestive membrane or blood-brain barrier), leads to scar tissue formation, reduce the sensitivity of hormones like insulin, and trigger autoimmune reactions.
Conditions Associated With Chronic Inflammation:
Some of the critical inflammatory messengers involved with chronic inflammation are TNF-a, NF-kB, IL-6, and IFN-y. CBD has been shown to inhibit all of these inflammatory messengers.
Conventional Inflammation Treatment
Inflammation is very common — as a result, we’ve developed many different approaches to treating inflammation over the years.
Some common forms of inflammation treatment include:
1. Dietary Changes
- Eliminate inflammatory-causing foods
- Identify and eliminate sources of food allergies
- Increase fiber and antioxidant-rich foods
- Increase anti-inflammatory foods(such as turmeric or ginger)
2. Anti-inflammatory Medications
3. Herbal Supplements
4. Lifestyle Changes
CBD For Inflammation: What The Research Says
CBD is a potent anti-inflammatory — interfering with inflammatory messengers at almost every level of the inflammatory response.
There are a few reasons why CBD can infiltrate and halt inflammation at so many levels:
- It stops the breakdown of anandamide— a powerful regulator of inflammation throughout the body.
- CBD (and other cannabinoids) are structurally similar to many of our inflammatory messengers(similar to our prostaglandins and leukotrienes).
- CBD activates the vanilloid receptors— responsible for regulating a different set of inflammatory messengers (TNF-a, IL-4, IL-12) .
- It slows the activation of immune cells such as T and B cells  — responsible for maintaining autoimmune-related inflammation.
- CBD triggers apoptosis(programmed cell death) in the immune cells involved with chronic inflammation 
What Inflammatory Messengers Does CBD Interact With?
Unlike most anti-inflammatory compounds that inhibit a select few of the inflammatory messengers driving inflammation, CBD stops almost all of them.
This makes it useful for many different types of inflammation — from allergic reactions and autoimmunity to sprains and strains.
Inflammatory Messengers Affected by CBD
|Inflammatory Messenger||Role in Inflammation||Inhibiting Cannabinoids|
|Histamine||Involved in allergic reactions and triggers rapid inflammation||THC |
|IFN-γ||Heavily involved in sustaining chronic inflammation||CBD |
|NF-kB||One of the key sustaining factors for psoriasis and involved with cancer growth||CBD |
|TNF-α||Triggers systemic (whole-body) inflammation||CBD THC |
|IL-2||Involved with inflammation related to cancer and autoimmune disease||THC
|IL-4||Regulates conversion of T-helper cells to Th2 cells and is heavily involved with autoimmunity||CBD THC CBN |
|IL-6||Triggers inflammatory cascade in acute inflammation and is a sustaining factor in chronic inflammation and autoimmunity||CBD |
|IL-8||Involved in acute inflammation from infectious diseases (viruses or bacteria)||CBD |
|IL-12||Involved in autoimmune conditions, including rheumatoid arthritis||CBD |
|IL-13||Both inflammatory and anti-inflammatory depending on the other messengers involved||THC
CBN CBD 
|Prostaglandins||One of the key regulators in starting and maintaining the inflammatory response||CBD |
|Leukotrienes||One of the key regulators in starting and maintaining the inflammatory response||CBD |
As you can see, CBD and many of the other cannabinoids have a lot to offer regarding inflammation — for a variety of different types of inflammation.
Because there are other cannabinoids with their specific anti-inflammatory effects, it’s best to find a full-spectrum extract for treating inflammatory conditions rather than a pure CBD extract.
Final Verdict: Using CBD for Inflammation
CBD is an excellent anti-inflammatory supplement — and as a result, it is used for many different types of inflammation.
Types of inflammation CBD works for:
The key to using CBD effectively for inflammation is to ensure you’re only using high-quality, full-spectrum extracts that have been confirmed to be free from contaminants through third-party testing.
You can use virtually any form of CBD to get anti-inflammatory benefits, but we recommend finding a high-potency oil due to the simplicity of use, cost-effectiveness, and long shelf-life.
CBD Dosage: What’s the Right Dose of CBD for Pain Relief?
Take a look at the label on any over-the-counter pain reliever and you can easily figure out how much you’re supposed to take for your symptoms. Finding the right dose of cannabidiol (CBD) for pain relief, however, isn’t that simple.
Enthusiasts rave about CBD’s potential to ease pain, reduce inflammation, relieve anxiety and promote sleep. However, there’s no conclusive research about just how much CBD a person needs to take in order to experience benefits.
There are very few human studies on CBD, and those that have been done include doses that are all over the map: In some studies, patients used 5 mg of CBD; in others, they took as much as 600 mg. To further add to the confusion, CBD comes in a number of forms — oils and tinctures, creams and lotions, pills, vaping, and edibles — and each one has differences in terms of bioavailability (the percent of active ingredient that gets into your bloodstream).
“There are no standard doses for patients,” says Rachna Patel, DO, a physician who does consultations about medical marijuana and CBD and sells her own line of CBD products. “Ultimately, it’s trial and error, but you have to go about it in a methodical way.”
Here are some tips to guide you on how to find the right CBD dosage for your pain relief and other symptoms.
1. Work with an expert
Many factors, such as your body mass index (BMI), specific health condition(s) you have, medications you take, your health history, and the form of CBD you plan to use can influence how much CBD you may need to treat your symptoms. Although CBD is different than medical marijuana — which contains CBD as well as THC, an intoxicating ingredient — a doctor who’s well-versed in cannabis (marijuana) is probably the best person to help you help you sort it out.
“I wouldn’t recommend starting CBD without the supervision of a physician,” says Dr. Patel, author of The CBD Solution. “Many times people purchase a CBD product, try a dose that that doesn’t work for them, switch products and spin their wheels. Or, worse, they develop side effects.”
Ask your rheumatologist or primary care provider to recommend an expert, or find an expert near you by searching the directory of members of the Society of Cannabis Clinicians or the database maintained by your state’s medical marijuana program (if it has one).
2. Do some math
Let’s say you and your doctor settle on a dose of 30 mg of CBD per day. Now what? The answer depends on which form of CBD you take.
Figuring out how much CBD is in capsules or gummies is simple — just read the supplement facts section on the label. (If it says 10 mg of CBD per capsule, you’d take three capsules to get your 30 mg of CBD a day.)
Oils and tinctures can be trickier because the packaging often states the amount of CBD in the entire bottle, not in a dropper. This calculator can help you figure out how many drops you need based on the strength of the product.
When it comes to CBD in topical form (creams, lotions, and salves), you’ll probably see the total amount of CBD in the container listed on the label. You’ll then have to divide that total by the number of millimeters in the package to determine how much is in each milliliter. For example, if you have a 50 ml jar of salve that contains 200 mg of CBD, there’s 4 mg per ml. You should then use a metric measuring spoon to scoop out 7.5 ml to get a 30 mg dose of CBD.
3. Expect some trial and error
No two patients respond to CBD in the same way. You and your doctor will probably need to adjust the dose either up or down until you hit the right balance of benefits without side effects. “A lot of it depends on your biochemistry and the way your liver breaks down these chemicals. There’s a wide variety of factors that come into play,” says Dr. Patel.
It can take a little while to get it right, so be patient. Many people do not see a difference in symptoms after one or two doses of CBD. It can take up to eight weeks of regular use to feel an impact, says Bridget Seritt, co-founder of the Canna-Patient Resource Connection, a Colorado-based organization that is working to protect patient rights and end stigma against those who choose cannabis as medicine.
4. If you have side effects, stop or lower the dose
CBD won’t get you high the way that cannabis with THC can, but it may still cause side effects. “The most common side effects are fatigue and lethargy, and in rare cases diarrhea,” says Dr. Patel, who notes that CBD that’s taken topically less commonly causes side effects. Topical CBD is best used to address pain in a single joint, rather than widespread pain, she adds.
No matter which form of CBD you use, pay attention to how you feel. If you notice any negative side effects, stop or lower the dose and consult your doctor.
A Guide to Finding Your Optimal CBD Dosage
CBD dosage: How much CBD Oil Should You Take?
While finding the right CBD dosage , consider the ailments and symptoms you are seeking to alleviate. Scientific research suggests that CBD Oil may benefit a diverse array of afflictions and conditions, including anxiety, inflammation, arthritis, rheumatoid arthritis, migraines, pain, premenstrual syndrome (PMS) and sleep. While each symptom requires a different dosage of CBD Oil to be most effective, it’s recommended to start low to help mitigate adverse effects or allergic reactions.
Start With a Low Dose of CBD
When implementing a CBD Oil regimen into your daily wellness routine, it is recommended to initially start with a small dosage of CBD Oil . As an example, you may start with a 10-15mg dosage daily during the first week. If you aren’t experiencing any alteration, you may try increasing the dosage to 20mg daily in the second week. Continue to incrementally increase the CBD Oil dosage until you intrinsically feel the effectiveness and it consistently provides relief.
In different clinical studies, CBD doses vary from as low as 20mg per day up to 1,500mg per day. WHO, The World Health Organization, even reports CBD dosages that range between 100mg per day and 800mg per day in some scientific studies. This then begs the question, “What is the maximum dose of CBD you should take?”
can you take too much CBD?
Clinical studies for CBD and Hemp Extract are very much in their infancy in comparison to medical research for other natural compounds. Experts still don’t have enough data or understanding around the potential long-term effects of using CBD. For this reason alone, we encourage you to discuss CBD usage and dosage with your doctor first.
While some studies have shown that dosages up to 1,500mg a day are not only tolerated but safe, we recommend starting with a low dosage. From there, work your way up based on how the Hemp Extract Oil makes you feel so as to avoid taking too much.
In 2019, a clinical study performed on mice revealed potential safety concerns around CBD’s interactions with other medications as well as CBD’s affect on the liver. While these mice were exposed to larger doses of CBD, it is still important to know; and before taking any supplement, it is always recommended to speak with your doctor first.