CBD Oil And Kidney Stones

Are you considering CBD to help manage Kidney Stones? Here are some of the best CBD products to help alleviate the symptoms of this condition. In the United States, approximately 11 percent of all men and 6 percent of women will experience kidney stones at some point in their lives according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD). [1] Furthermore, these yellow or brown pebble-like formations are more common in… Kidney stones can be incredibly painful and accompanied by nausea. Learn more here about how medical marijuana is used to treat kidney stones.

Compare The Best CBD for Kidney Stones For 2022

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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No other flavors

Approximately 300 drops total


Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
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No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients


The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test


Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team


cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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60-Day Satisfaction Guarantee

Dropper is a bit shaky

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices


CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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No other flavors

A bit pricey compared to competitors

Approximately 100 drops total


This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes


A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee


Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Royal CBD Full Spectrum CBD Oil
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Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes

Shipping not specified on website

More flavors to choose from

3rd party lab result is currently not available on website

Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate


Excellent products and superb customer service. Whenever you want to ask them about the dosage, recommended consumption methods, or which CBD oil will work best for you, just give them a call, send them a message, or get in touch with their social media channels. They won’t leave you with any unanswered questions.

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How CBD May Help With Kidney Stones

The mentioned benefits of CBD may offer relief for individuals suffering from symptoms of kidney stones (1) .

Cannabidiol , more popularly called CBD, is one of the many active chemical compounds present in the cannabis plant (2) . This compound may interact with the body’s endocannabinoid system (ECS) (3) .

The ECS consists of various cannabinoid receptors, including CB1 and CB2 receptors located in the nervous and immune systems.

The interaction of CBD and these two receptors may produce analgesic (pain-relieving) and anti-inflammatory benefits (4) . These characteristics may help with pain due to kidney stones.

Poor diet, excess body weight, certain medications or supplements, or some medical disorder can cause kidney stones to form. An individual’s urine may become concentrated, crystallizing minerals and chemicals (5) .

A small kidney stone as small as a grain of sand may remain or move out of the kidney while causing minimal pain and discomfort. However, some stones as large as a pebble or even a golf ball can block some parts of the urinary system and cause extreme pain (6) .

Acute renal colic is characterized by severe pain caused by the presence of a kidney stone in the urinary system (7) .

Meanwhile, s tudies have noted how CB1 and CB2 receptors in the ECS play essential roles in renal function and dysfunction (8) .

Other symptoms of kidney stones are severe lower back pain, nausea and vomiting, fever, or foul-smelling urine that may appear bloody or cloudy (9) .

Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen are often administered for pain relief to individuals with kidney stones (10) .

On the other hand, research has shown that cannabidiol (CBD) may contain pain-relieving properties that may help deal with chronic pain (11) . The compound may also possess anti-nausea and antiemetic (anti-vomiting) benefits (12) .

CBD may also interact with 5-HT1A receptors, commonly named serotonin receptors (13) . Serotonin, the chemical hormone that regulates mood, may help with nausea and vomiting (14) .

Benefits of Using CBD for Kidney Stones

A recent study indicated that topically applied CBD provided considerable pain relief for individuals suffering from chronic back pain (15) .

Kidney stones may induce severe lower back pain (16) .

Additionally, a British Journal of Pharmacology study suggested that CBD may possess therapeutic effects that may reduce nausea and vomiting induced by chemotherapy or other medical treatments (17) .

Nausea and vomiting are common symptoms associated with kidney stones (18) .

According to 2019 research, opioids are prescribed to individuals suffering from pain around the kidney area due to kidney stones . Opioid use is prevalent among people who have a history of kidney stones (19) .

However, potent pain medications like opioids are linked to adverse side effects such as confusion, nausea, slowed breathing, addiction, and physical dependence (20) .

Meanwhile, CBD may possess anti-inflammatory and pain-relieving properties that may help with various medical conditions (21) .

In addition, a review from the World Health Organization states that CBD is not linked with addiction or substance abuse (22) .

Choosing the CBD Product Type to Use for Kidney Stones

When choosing a CBD product , consider the severity of your medical condition, the form of CBD you prefer, the type of CBD extract, and carrier oil.

CBD Administration Methods

CBD oil tinctures are taken sublingually or under the tongue with the help of a dropper or oromucosal spray. After administering the compound, individuals should wait for one to two minutes before swallowing (23) .

Edibles such as CBD gummies and capsules are administered through ingestion. The compound passes through the digestive tract before entering the bloodstream (24) .

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Meanwhile, smoking or inhaling CBD using vape pens is the quickest method for individuals to feel the benefits of the compound (25) .

However, caution should be exercised when considering vaping due to the health risks it is associated with, such as lung damage (26) .

Lastly, topical CBD such as CBD creams and balms are usually for localized pain relief (27) . This method may also be helpful for symptoms of kidney stones .

A case study stated that topically applied CBD cream delivered significant pain relief for individuals with lumbar compression fractures (injury caused by trauma) (28) .

Lumbar compression fractures and kidney stones may cause back pain (29-30) .

Still, you should first consult your doctor for recommendations on the best CBD product or supplement for kidney stones or any medical conditions.

CBD Extracts

The types of CBD oil extracts are:

  • Broad-spectrum CBD oil
  • Full-spectrum CBD oil
  • CBD isolate

Broad-spectrum CBD oil contains compounds and cannabinoids such as cannabidiol , terpenes, and flavonoids (31) . However, this type of oil does not contain any THC ( tetrahydrocannabinol ).

THC is a chemical compound of cannabis that produces psychoactive effects or the feeling of being high (32) .

Terpenes give cannabis plants their unique scent. Flavonoids are plant compounds that may possess antiviral, antioxidative, and anti-inflammatory health benefits (33) .

Meanwhile, full-spectrum CBD oil contains all the cannabinoids and cannabis -derived compounds, including less than 0.3% THC concentration.

The presence of all the cannabis compounds in a full-spectrum CBD oil may deliver the entourage effect .

The entourage effect is the occurrence wherein all the active ingredients of cannabis plants work better when administered alongside each other (34) .

Lastly, CBD isolates are pure CBD, usually in powder form. Isolates do not contain cannabinoids or compounds.

Individuals may opt for broad-spectrum CBD or CBD isolates if they prefer to feel CBD’s therapeutic effects without the psychoactive effects of THC .

Carrier Oils

Upon the extraction of CBD from the hemp plant , the compound is infused into a carrier oil like hempseed oil or MCT oil (35) .

Note that the terms “hempseed oil” and “ hemp oil ” have considerable differences.

Hempseed oil is from pressed seeds of hemp. Hempseed oil is also rich in fatty acids but does not have CBD (36) .

H emp oil , a term often used to refer to CBD oil , is an essential oil from the flowers and leaves of hemp plants .

CBD Dosage for Kidney Stones

The Food and Drug Administration ( FDA ) does not authorize the use of CBD to treat any medical conditions (37) . Thus, there is no set CBD dosage for kidney stones .

Research on the safety and side effects of CBD suggests that the human body may tolerate up to 1,500mg of CBD each day (38) .

Nonetheless, it is advisable to talk to a medical professional for advice on a suitable CBD dosage for kidney stones or any medical illness.

How Long Does CBD Take to Help Kidney Stones ?

The administration method and CBD form may determine how long the compound takes to affect the human body.

Due to the compound’s direct entrance to the bloodstream, CBD tinctures have an onset time of 15 to 30 minutes (39) . CBD topicals like creams and balms have the same onset time (40) .

Meanwhile, edibles such as CBD gummies and capsules have an onset time of 30 minutes to 90 minutes (41) .

Lastly, vaping CBD offers the fastest onset time of 2 to 15 minutes (42) . However, it is essential to remember that vaping may cause detrimental effects to your health, such as pulmonary disease (43) .

Talk to a medical expert before taking CBD oil for kidney stones .

How Long Will CBD Help With Kidney Stones ?

There are no studies that determine the duration of the effects of CBD in the system.

Cannabidiol may linger in the body depending on dosage, the frequency of use, and administration method (44) .

Is It Safe to Take CBD With Kidney Stones ?

Currently, the Food and Drug Administration ( FDA ) has not approved CBD to treat kidney stones .

For the safety of consumers, the attorney general (AG) in the United States has encouraged the FDA to perform extensive studies on how cannabis compounds work, especially the interaction between the compounds and other drugs (45) .

Nevertheless, CBD has been reported to be safe and well tolerated by the body (46) . Still, individuals with kidney stones should seek the advice of a medical professional first before taking CBD for their symptoms.

Risks and Side Effects of Using CBD for Kidney Stones

In general, taking CBD may cause minor side effects such as (47) :

  • Appetite loss
  • Fatigue
  • Dry mouth
  • Drowsiness

People who suffer from kidney stones are given prescription medications such as opioids or over-the-counter (OTC) pain relievers like ibuprofen (48) .

However, CBD may interact with certain medications and induce side effects such as increased drowsiness, tiredness, accidental falls, and hazards when driving (49) .

Inform your physician before taking CBD products alongside any prescription medication.

Legality of CBD

The passing of the 2018 Farm Bill made CBD products containing less than 0.3% THC federally legal in the United States (50) .

Still, it is essential to verify state laws before purchasing and traveling with CBD products .

Overview of Kidney Stones

Causes of Kidney Stones

Determining the type of kidney stone is vital to finding out the cause and treatment plans for reducing kidney stone symptoms.

The different types of kidney stones are (51) :

  • Calciumstones: Most common kidney stones are made from calcium oxalate . This substance is absorbed from your diet or produced by the liver. High doses of vitamin D, certain fruits and vegetables, and specific migraine medication may increase the risk of oxalate in urine.
  • Cystine stones: These are formed due to a hereditary disorder called cystinuria which causes kidneys to eliminate amino acids .
  • Struvite stones: These stones form due to a urinary tract infection and grow large fast with little to no symptoms on the body.
  • Uric acid stones: Uric acid stones are formed due to the loss of too much fluid or chronic diarrhea. Individuals with high-protein diets or diabetes have high risks for these types of stones.

Symptoms of Kidney Stones

Sometimes kidney stones will not cause any symptoms. However, if a stone becomes stuck in the ureter (the tube that connects the kidneys to the bladder) and blocks urine flow, this may cause pain and inflammation of the kidneys and ureter (52) .

Other symptoms of kidney stones include (53) :

  • Severe pain in the back, side, and lower ribs
  • Pain at the groin and lower abdomen
  • Nausea and vomiting
  • Burning sensation while urinating
  • Foul-smelling and unnaturally colored (red, pink, or brown) urine

Alternative Treatment for Kidney Stones

Treatment for kidney stones may differ depending on the cause and type of stone.

Most small kidney stones do not need invasive surgeries or serious medical interventions if such conditions have minimal symptoms.

Individuals may be able to pass a small stone by (54) :

  • Drinking water: Drinking water may dilute urine and prevent the formation of kidney stones .
  • Takingpain relievers: Passing a kidney stone may induce discomfort. Doctors can recommend medications like naproxen sodium or ibuprofen for pain management .
  • Takingalpha-blockers: This type of medication relaxes the ureter muscles, helping the body pass the kidney stone faster and with minimal pain.
  • Taking potassium citrate: Doctors can also suggest potassium citrate, which is a dietary supplement used to decrease urine stone or kidney stone reproductio n (55) .

You should first consult your doctor for a recommendation on the best supplement or medication to manage kidney stones.

If the kidney stones are too large or are causing kidney damage, bleeding, or urinary tract infections , doctors may suggest a more extensive approach, such as surgery (56) .

Product Frequently
Asked Questions

How can CBD help with kidney stones?

Kidney stones may cause severe lower back pain, nausea, and vomiting (57) .

Meanwhile, researchers examining CBD’s purported benefits noted that the compound may contain analgesic (58) , anti-nausea, and antiemetic properties (59) .

What evidence or research exists to say that CBD helps with kidney stones?

Kidney stone is linked to pain, nausea, and vomiting (60) .

Studies suggest that CBD may reduce the feeling of nausea and vomiting of individuals undergoing chemotherapy (61) .

CBD does not have any direct therapeutic benefits for kidneys. However, individuals with kidney disease may use cannabis for symptom control, such as relieving pain caused by the disease (62) .

Opioids are potent painkillers prescribed to individuals with kidney stones (63) . However, these drugs may cause physical dependence or addiction (64) .

Meanwhile, a 2017 report on CBD has discussed that the compound is safe and non-addictive (65) .

Is there any evidence that CBD can make kidney stones worse?

No current evidence suggests that CBD can negatively affect kidney function or kidney health (66) . However, using CBD may induce side effects such as lightheadedness, sleepiness, and diarrhea (67) .

Meanwhile, uric acid stones are most likely to form in individuals who experience an overt fluid loss due to chronic diarrhea (68) .

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Thus, it is crucial to consult your doctor before taking any CBD products for kidney stones .

Will CBD interact with any current medication I may be taking for kidney stones?

Opioids and ibuprofen are medications given to individuals with kidney stones (69) .

However, CBD may interact with certain drugs and cause increased drowsiness, fatigue, accidental falls, and accidents when driving (70) .

Consulting your doctor before taking CBD products alongside these medications is advised.

Are there other treatments I should consider alongside CBD to help with kidney stones?

Treating kidney stones may vary depending on their size. Small kidney stones may only require minimal medical attention. In some cases, taking pain relievers may help reduce pain and discomfort (71) .

Medications such as alpha-blockers are used to relax the muscles in the ureter and allow the body to easily pass kidney stones (72) .

Doctors may also offer dietary supplements. While these supplements may not get rid of kidney stones, they may help impede the production of the stones (73) .

However, if the kidney stones are large and cause severe pain , doctors may suggest surgical procedures to deal with the medical issue (74) .

Can I fail a drug test if I use CBD for kidney stones?

CBD does not contain any psychoactive properties, meaning it will not cause a euphoric high (75) .

However, trace amounts of THC in CBD products may build up in the system after frequent use (76) and may result in a positive drug test.

What is the dosage for kidney stones?

The proper CBD dosage may vary depending on factors like an individual’s specific health condition, genetics, diet, and exercise (77) .

CBD Oil And Kidney Stones

In the United States, approximately 11 percent of all men and 6 percent of women will experience kidney stones at some point in their lives according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD). [1]

Furthermore, these yellow or brown pebble-like formations are more common in Americans with a family history of kidney stones or those that have a medical condition that increases their risk of developing stones. This includes those diagnosed with chronic kidney disease, obesity, or repeated urinary tract infections.

Certain medications—like diuretics, calcium-based antacids, and anti-seizure medications—can also cause kidney stones. And if you’ve had them once, you’re more likely to get them again. How do they form?

Kidney Stone Formation

The NIDDKD indicates that kidney stones can form if there are high levels of specific minerals that are present in the urine.

Based on these minerals, the four types of kidney stones are:

  1. Calcium stones (which includes calcium oxalate and calcium phosphate stones). These are the most common types of kidney stones and occur when your body has extra calcium that is not used by your bones and muscles. Though, eating a high calcium diet does not necessarily mean that you’ll develop calcium stones.
  2. Uric acid stones. If you eat a lot of fish, shellfish, and organ meat, you may be more prone to developing uric acid stones. Uric acid is also what causes gout, a condition that can cause high levels of pain due to crystals forming around the joints. [2]
  3. Struvite stones. Struvite stones can occur if you have a urinary tract infection. The NIDDKD states that these particular stones are known for forming and growing rather quickly.
  4. Cystine stones. This type of stone is more common in people with cystinuria, a genetic condition in which cysteine—which is an amino acid—leaks into the urine.

All four of these types of kidney stones can cause severe pain, particularly if they get stuck in the urinary tract and are unable to pass on their own.

Fortunately, research has found that lab grade, full spectrum CBD (cannabidiol) can help ease this type of chronic pain .

How CBD Works

CBD is one of hundreds of cannabinoids found within the hemp plant, of which tetrahydrocannabinol, or THC, is probably the most well-known. [3] Though, unlike THC, CBD does not create a psychoactive effect.

The endocannabinoid system interacts with cannabinoids, both those made by your body and those ingested via hemp and cannabis substances. These cannabinoids attach to the body’s CB1 and CB2 receptors, resulting in a few rather positive health benefits.

The National Institute on Drug Abuse (NIDA) shares that some of the health benefits provided by the cannabinoids found in medical cannabis and various CBD products include reduced inflammation and individuals having fewer seizures. [4]

For those suffering from kidney stones specifically, CBD can also help provide lower levels of pain. This is critical as many kidney stone sufferers report experiencing excessive amounts of back pain near where the kidneys are located.

Research: CBD for Pain

Research conducted in this area confirms CBD’s positive impact on kidney stone pain and overall kidney health.

For instance, one study published in the American Journal of Physiology-Renal Physiology shares that cannabinoids such as CBD can help improve kidney health by stimulating the CB1 and CB2 receptors. [5]

Another study took an in-depth look at the renal benefits CBD can provide chemotherapy patients, a demographic which is more susceptible to developing toxicity in the kidneys. [6]

In this case, researchers noted that CBD offers an anti-inflammatory effect and decreases cell death in the kidneys while also improving total kidney function.

Proper CBD Dosing

Like with any other health supplement, proper dosing is important when it comes to safe and effective pain management for kidney stones.

According to Medscape, just one dose of CBD “is likely insufficient,” with most therapeutic doses ranging somewhere between 2.85 and 50 mg a day depending on the individual and his or her response to this particular cannabinoid. [7]

However, since cannabis use is now becoming more widely accepted for medical purposes versus strictly for recreational use, Medscape goes on to say that more studies need to be conducted in this area to determine proper dosing for kidney stones and other chronic kidney diseases specifically.

Choosing CBD Product Type

In addition to using the right dose, it’s also important to choose the right CBD product type.

Some of the options in this area include CBD oil and hemp oil, tinctures, sprays, and medical marijuana. It is important to note that medical marijuana also contains THC, so this is something to keep in mind if you want a product that does not offer a psychoactive effect.

That said, some CBD products also contain THC, making it important to know what’s in the products you’re interested in trying for chronic pain relief if you’re concerned about the common effects of cannabis or testing positive on a work-related drug test.

CBD’s Potential for Side Effects

In a Critical Review Report, the World Health Organization (WHO) states that CBD has failed to produce any major side effects when tested in various human studies. [8]

The WHO adds that many open label and clinical trials have also found that this hemp plant cannabinoid “it is generally well tolerated, with a good safety profile.”

In the end, if you’re concerned about whether CBD can help reduce your kidney stone pain safely and without unwanted side effects, you can always consult with medical professionals who are familiar with this cannabinoid and ask them for guidance when making the right decision for you.

This expert can also help you figure out how much CBD you should be taking a day to achieve your desired relief from kidney stone pain.

Medical Marijuana and Kidney Stones: Can Patients Benefit?

Kidney stones (also known as renal calculi or urolithiasis) are masses of minerals and salt that form in your kidneys. They can also sometimes originate in the ureters, bladder, and urethra, reports Healthline (18).

Many patients suffering from kidney stones have reported that medical cannabis use eases their pain and nausea. A 2017 study from the American Journal of Physiology-Renal Physiology details exactly how medical cannabis can ease kidney diseases, including stones. “The two different types of receptors (CB1 and CB2) that are activated by the pharmacologically active ingredients of cannabis are found in numerous tissues, including the kidneys,” according to the medical journal.

Furthermore, “experimental studies suggest that stimulation of these receptors using pharmacologic agents or their naturally occurring ligands could have both deleterious and beneficial effects on the kidneys, depending on receptor distribution, type of renal insult, or the timing of the activation during acute or chronic states of kidney injury (13).”

Interestingly, a Korean clinical research study on a terpene-combination drug called “RowatinexⓇ” has shown effectiveness at expulsing more kidney stone remnants 4 weeks after shock wave lithotripsy than traditional tamsulosin and analgesic (22). A meta-analysis has supported this as well. This drug is a combination of terpenes including pinene, camphene, borneol, anethole, fenchone and cineol—many of these are found in medical cannabis. However, like cannabinoids and terpenes, Rowatinex also does not currently have FDA approval and requires further studies (23).

Medical marijuana—or medical cannabis—has anecdotally helped many patients suffering from debilitating symptoms and side effects of decreased kidney function. What does research tell us about the role the endocannabinoid system plays in renal function?

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The ECS and the Kidneys

The endocannabinoid system (ECS) is made up of specialized, fat-based neurotransmitters, which are activated by cannabinoids found in the cannabis plant—such as Δ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD) — when they come into contact with the two different types of cannabinoid receptors (CB1 and CB2) (1). Cannabinoids may also act on other receptors in our body beyond CB1 and CB2 to cause effects. These receptors are found in numerous tissues throughout the body, including the kidneys (13).

The role of the ECS in renal pathology—which deals with diagnosis and characterization of medical diseases of the kidneys—is an emerging area of research. It has been studied primarily in the context of CB receptors. The current research suggests that targeting the ECS may be of diagnostic and therapeutic value (4).

Endocannabinoids, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are responsible for a variety of processes in our bodies (17). These processes include regulating sleep and pain perception, as well as modulating our immune system to slow down inflammation .

According to a review of recent findings related to CB receptors in the kidneys, “Emerging studies using isolated cells, rodent models, and human studies have identified a critical role for the endocannabinoid system in renal function and disease. Thus, therapeutics that modulate the activity of CB1 and CB2 in renal disease could become clinically relevant (5).”

Further research is needed in this area to reduce the adverse effects of cannabis while advancing its potential beneficial impacts on renal function in various types of kidney diseases (13 ).

Can Cannabinoids Treat Kidney Stones?

Symptoms of kidney stones can include severe pain, nausea, vomiting, fever, chills and blood in your urine. For three of these related symptoms—pain, nausea, and vomiting—there is significant research that suggests medical cannabis can help.

Some medical cannabis users report using the plant to treat the pain, nausea, and vomiting caused by kidney stones. Some patients prefer to use medical cannabis in the place of opioid medications prescribed for the severe pain associated with kidney stones (3 ).

A 2008 report out of the Journal of Pharmacology and Experimental Therapeutics explored if cannabidiol could treat toxicity in the kidneys experienced by patients on cisplatin chemotherapy. The researchers found that cannabidiol was associated with reduction in inflammation, reduced cell death in the kidneys, and improved renal function in mice. It was also associated with marked improvement of compromised renal function in mice. The authors conclude that, “our results suggest that the nonpsychoactive cannabinoid CBD may be of significant therapeutic benefits against the renal complications of cisplatin chemotherapy by attenuating oxidative/nitrosative stress and cell death (12).”

Medical Cannabis and Chronic Pain Management: Replacing Opioids

Chronic pain prevalence in patients that deal with kidney stones and other renal diseases is well-documented. It is often managed through prescription opioids or acetaminophen prescribed by the patient’s doctor.

Both the short term and chronic use of prescription opioids has been associated with increased morbidity and mortality, which presents a clear need for alternative methods for pain relief (21). Access to medical cannabis has been connected with a decrease in opioid prescriptions as well as dose reductions (15) . Acetaminophen, or Tylenol, is a decent alternative to opioids, however, it is easily quite toxic and lethal at doses over 4 grams daily.

The National Academies concluded that substantial evidence exists for the use of cannabis and cannabinoids to treat chronic pain while causing no fatal overdoses (24). Findings suggest that medical cannabis users managing chronic pain with cannabis—as an adjunct of or in place of opioids—may “reduce the personal and social harms associated with addiction, particularly in relation to the growing problematic use of pharmaceutical opiates (7) .”

Historically, cannabis has been recommended for a wide range of ailments including as a spasmolytic— a drug that relieves spasm of smooth muscle— for cases of renal colic, which is a type of pain you get when urinary stones block part of your urinary tract. Renal colic is more often caused by larger kidney stones (20).

Historical documentation of medical cannabis applications also tells us that it was used to facilitate the excretion of small kidney stones in patients (19) . Terpenes like camphene, borneol, and cimeole found in Rowatinex and cannabis also have antispasmodic effects in rodent smooth muscle models. Although cannabis and terpenes could have a therapeutic role in chronic pain management, further clinical trial investigation is needed (22).

Medical Cannabis and Nausea

Considerable evidence demonstrates that manipulation of the ECS regulates nausea and vomiting in humans and animals. Preclinical and clinical research indicates that cannabinioids, including THC and CBD, may be effective clinically for treating both nausea and vomiting (14).

Some studies that have investigated cannabinoids such as THCA have found that this cannabinoid has heightened potential for treating nausea and vomiting. According to one mouse study, THCA proved to be “a more potent alternative to THC in the treatment of nausea and vomiting (25).” More clinical research is needed in this area to fully explore the different cannabinoids and their medical value.

Medical Cannabis and Inflammation

Cannabinoids are potent anti-inflammatory agents, even more potent than Vitamin C or E ( 26 ). In CKD and other kidney diseases, inflammation occurs within kidney tissue and other organs. Pericarditis, a prevalent symptom of CKD and dialysis, is abnormal heart inflammation , and general inflammation is one of the most common conditions targeted with medical cannabis. One of the most popular reports demonstrating that CBD is good for inflammation was published in a 2009 edition of Future Medicinal Chemistry.

“Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system,” according to the study. “The fact that both CB1 and CB2 receptors have been found on immune cells suggests that cannabinoids play an important role in the regulation of the immune system.” Since inflammation is the body’s response to harm and injury, it would make sense that medical cannabis helps with symptom management of CKD and dialysis (27).

Interestingly, recent studies have shown a mixed protective/deletrious role of cannabinoid receptors in the kidney in response to inflammation and tissue injury (4). Ironically, CB1 receptor activation could make kidney inflammation worse while CB2 receptor activation on immune cells reduces inflammation. It may be best to selectively use a CB1 antagonist and CB2 agonist for kidney-related inflammation according to reviewed studies. Follow up systematic reviews on CBD as an anti inflammatory and antioxidant continue to be published with new findings such as the fact that CBD is a more potent antioxidant than Vitamin C or E (2).

Causes, Symptoms & Treatment of Kidney Stones

When crystal-forming agents, including calcium, oxalate, and uric acid are not diluted enough in the urine, kidney stones develop, reports the Mayo Clinic (8).

There are four types of kidney stones: calcium, struvite, uric acid, and cystine. As noted, passing kidney stones brings on severe pain, especially in the side and in the back (below the ribs). Common symptoms of kidney stones include pain that radiates to the lower abdomen and groin, a burning sensation while urinating, fever and chills, nausea , and vomiting. Monitor kidney health by staying well-hydrated and being aware of these warning signs.

Larger kidney stones in particular are known for being incredibly painful, with symptoms that may include pain, bleeding, inflammation, or infection. However, these symptoms may not usually develop until the stone has started to move through the urinary tract (9). According to research done by PubMed, “Stone formation is highly prevalent, with rates of up to 14.8% and increasing, and a recurrence rate of up to 50% within the first 5 years of the initial stone episode. Medical conditions such as obesity, diabetes, hypertension (high blood pressure) and metabolic syndrome are considered risk factors for stone formation, which, in turn, can lead to hypertension, chronic kidney disease (CKD) and end-stage renal disease (6).”

There are other possible causes of kidney stones including dehydration, lack or excess of exercise, obesity, weight loss surgery, or consuming foods high in sodium and sugar (e.g. high fructose corn syrup). Infections and family history of renal disease could be significant for some people (11).

Treatment for kidney stones varies greatly. Smaller kidney stones may be treated by drinking water and taking pain relievers, while more surgery is sometimes needed to remove larger kidney stones. Other treatments for kidney stones may include diuretic medications like tamsulosin, tunnel surgery, and lithotripsy, which uses sound waves to break up calcium masses, all of which are “tailored according to the type of stone,” reports Healthline (18 ) . Infections from kidney stones can be serious and may require IV antibiotics or even hospitalization.

Note: Veriheal does not intend to give this as professional medical advice. Do not attempt to self-diagnose, or prescribe treatment based on the information provided on this page. Always consult a physician before making any decision on the treatment of a medical condition.