Using CBD oil for ulcerative colitis may reduce inflammation in the digestive tract. Learn what research says and how to dose CBD for IBD. Here are some of the best CBD products for Ulcerative Colitis (UC), a chronic inflammatory disease which affects the large intestine and causes ulcers.
Using CBD for Ulcerative Colitis
Lindsay Curtis is a health writer with over 20 years of experience in writing health, science & wellness-focused articles.
Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Robert Burakoff, MD, MPH, is board-certified in gastroentrology. He is the vice chair for ambulatory services for the department of medicine at Weill Cornell Medical College in New York, where he is also a professor. He was the founding editor and co-editor in chief of Inflammatory Bowel Diseases.
Ulcerative colitis (UC) is a chronic disease that affects the large intestine (colon), causing inflammation and small sores (or ulcers). UC symptoms include diarrhea, abdominal cramps and pain, bloody stool, and the need to pass stool frequently.
There is no cure for ulcerative colitis, so treatment prioritizes symptom relief and reducing flare-ups. Many people with ulcerative colitis turn to alternative treatments, such as cannabidiol (CBD), to take control of the disease and improve their quality of life.
Read on to learn more about how CBD may be a useful supplemental therapy in the management of UC symptoms.
Tinnakorn Jorruang / Getty Images
Inflammation, CBD, and Ulcerative Colitis
Cannabis plants contain chemicals called cannabinoids, which are compounds unique to the plant. The two primary cannabinoids are:
- Tetrahydrocannabinol (THC), which has psychoactive effects that make a person feel “high”
- Cannabidiol (CBD), which has no psychoactive effects but can provide a number of therapeutic benefits
Both CBD and THC interact with the endocannabinoid system (ECS) in the body. The ECS is a complex biological system that regulates cardiovascular, nervous, and immune system functions.
CBD binds to and activates receptors in the brain that create a therapeutic effect in the body, helping users find relief from painful symptoms without feeling impaired.
CBD has many therapeutic properties and is a known anti-inflammatory, antimicrobial, and antioxidant. Thanks to its anti-inflammatory properties, CBD may be a potential therapeutic treatment for ulcerative colitis.
CBD for Ulcerative Colitis Symptoms
CBD has been explored in several studies as a potential treatment for ulcerative colitis. Research shows that CBD may potentially help reduce inflammation in the gastrointestinal system caused by inflammatory bowel diseases (IBD), such as ulcerative colitis.
One study found that participants with UC who took 50 milligrams (mg) of CBD oil twice a day, increasing to 250 mg per dose if needed and tolerated, experienced significant improvements in their quality of life. However, more research and follow-up studies are needed.
Another study analyzed the efficacy of CBD use in adults with ulcerative colitis. The study concluded that CBD extracts may help alleviate symptoms of IBD and UC.
Although more research is needed, current study results show promise that CBD may be beneficial for treating symptoms of ulcerative colitis.
Are There Any Side Effects?
Though CBD is generally well tolerated, you may experience some side effects. Common side effects include:
- Changes in mood (e.g., irritability)
- Decreased appetite
- Dry mouth
CBD and Your Liver
CBD is metabolized by the liver, and large doses may lead to liver toxicity. Talk with your healthcare provider before using CBD. If you are on any prescription medications, they may recommend regularly monitoring your liver through bloodwork to ensure CBD is safe for you.
How to Use CBD for Ulcerative Colitis
While CBD won’t cure ulcerative colitis, it may help make your symptoms more manageable and help reduce flares.
There are many different forms of CBD, and you may need to try different delivery methods before finding the one that is right for you.
CBD is available in:
- Edibles (e.g., gummies, CBD-infused beverages)
- Plants (to be inhaled/smoked)
- Capsules and pills
- Tinctures and oils
- Topicals (e.g., lotions, creams)
To date, CBD has only been approved by the Food and Drug Administration to treat epilepsy. As a result, there is no standard recommended dosage of CBD for treating ulcerative colitis.
Shopping for CBD
When shopping for CBD, you will notice different types available. These include:
- Full-spectrum CBD: Contains all the natural components found in the cannabis plant, including terpenes, flavonoids, fatty acids, and cannabinoids. Full-spectrum CBD products contain trace amounts of THC. These compounds work in synergy in the body to obtain the desired therapeutic effects.
- Broad-spectrum CBD: Similar to full-spectrum CBD, broad-spectrum CBD contains compounds in the cannabis plant, but with all traces of THC removed, so you will not experience any mind-altering effects.
- CBD isolates: All other cannabinoids, terpenes, and flavonoids are removed to create a 99% pure CBD product.
For the best results, look for broad-spectrum or full-spectrum CBD products. These may combine the effects of multiple cannabis compounds that work together in synergy, creating an “entourage effect” to offer the most health benefits.
Because CBD is still a relatively new therapeutic option for managing different health conditions, including inflammatory bowel diseases, there is currently no recommended standard dosage.
In one study, patients with ulcerative colitis were given 50 mg of CBD oil twice a day. Some participants were able to increase to as much as 250 mg twice a day for a period of 10 weeks.
Another study also recorded dose ranges of 50 mg to 250 mg CBD capsules twice daily. Many participants were able to tolerate the higher dosage and saw improvements, though the study authors suggested that more research is needed.
As with many medications, it’s best to start with a lower dose and gradually increase the amount of CBD to determine the appropriate dosage.
Talk to Your Healthcare Provider
It’s important to talk with your healthcare provider before adding any supplemental therapy, such as CBD, to your ulcerative colitis treatment. They will be able to determine if CBD will be beneficial for your individual case and can recommend the right dosage.
How to Buy CBD
With so many different options available, it can be daunting to shop for CBD. CBD is generally safe and well tolerated, but the industry is poorly regulated, and consumers should be aware of what to look for before purchasing CBD.
You’ll want to carefully read the label of any products you are considering and look for:
- Amount of CBD per serving
- Suggested use/dosage
- Type (full-spectrum, broad-spectrum, or isolate)
- List of ingredients
- Manufacturer and distributor name
You’ll also want to consider:
- Cannabis source: Ensure the product you are purchasing is sourced from a company that ensures the quality and safe cultivation of their plants. Look for products that come from organic cannabis/hemp plants when possible.
- Certificate of Analysis (CoA): CoAs are conducted by independent, accredited labels that verify third-party testing of the products.
- Customer reviews: Testimonials from other users can tell you a lot about a product’s efficacy.
Avoid products and vendors that make broad, definitive statements or promises of a “cure” for something. If you are currently taking any other medications or supplements for your UC, speak with your healthcare provider before using CBD, as it may interact with other medications you are taking.
A Word From Verywell
People with ulcerative colitis may want to consider alternative treatments such as CBD to help manage their symptoms. It’s important to remember that while CBD may help improve your symptoms, it will not treat or cure the condition.
CBD is best used as a supplemental therapy alongside conventional treatments recommended by your healthcare provider, as well as dietary modifications. As with any supplement or medication, talk with your healthcare provider before trying CBD.
Frequently Asked Questions
Cannabinoids have anti-inflammatory properties that may make them helpful in managing symptoms of gastrointestinal diseases like ulcerative colitis. Research suggests CBD is a promising therapeutic for inflammatory bowel diseases, helping reduce mucosal lesions, ulceration, and inflammation associated with IBD. CBD may also help manage gastrointestinal pain, as well as secondary symptoms that come with IBD, such as anxiety, nausea, and sleep disturbances.
The cannabis plant (to be smoked/vaped) comes in different strains, with varying CBD and THC levels. CBD-dominant cannabis strains may provide the best relief for inflammation. These strains tend to be high in the terpene called myrcene, which helps reduce inflammation.
There are many delivery methods for CBD, including edibles (e.g., gummies), flowers, oils, tinctures, topicals, and suppositories. Finding the right one for you may require a little trial and error. The best method for you depends on personal preference and how quickly you may need relief. For example, you may get relief from painful symptoms sooner by vaping oil vs. consuming an edible. Start off with smaller doses and gradually increase the amount you use until you find the amount that offers you relief from your symptoms. Make sure to talk with your healthcare provider before you begin use.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
National Institute of Diabetes and Digestive and Kidney Diseases. Symptoms and causes of ulcerative colitis.
Blaskovich MAT, Kavanagh AM, Elliott AG, et al. The antimicrobial potential of cannabidiol. Commun Biol. 2021;4(1):7. doi:10.1038/s42003-020-01530-y
Kafil TS, Nguyen TM, MacDonald JK, Chande N. Cannabis for the treatment of ulcerative colitis. Cochrane Database Syst Rev. 2018;(11). doi:10.1002/14651858.CD012954.pub2
Gyires K, Zádori ZS. Role of cannabinoids in gastrointestinal mucosal defense and inflammation. Curr Neuropharmacol. 2016;14(8):935-951. doi:10.2174/1570159×14666160303110150
Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in anxiety and sleep: a large case series. Perm J. 2019;23:18-041. doi:10.7812/TPP/18-041
Surendran S, Qassadi F, Surendran G, Lilley D, Heinrich M. Myrcene—what are the potential health benefits of this flavouring and aroma agent? Front Nutr. 2021;8:699666. doi:10.3389/fnut.2021.699666
CBD for Ulcerative Colitis – August 2022
Can CBD Help With Ulcerative Colitis, and if So, How?
- Ulcerative colitis (UC) is a chronic inflammatory disease in a category known as Inflammatory Bowel Disease (IBD) and is known to affect the large intestine and cause sores, or ulcers, in the digestive tract (1) .
- Aminosalicylates have been the primary means of treating colitis for many years, with doctors aiming to reduce inflammation in IBD patients and improve their quality of life . Physicians may also prescribe medications, such as corticosteroids and antibiotics, to treat the symptoms of UC (2) .
- Studies have shown that CBD’s anti-inflammatory properties may help treat colitis (3) . Several studies report that CBD may prevent colon injury (4) , inhibit disturbances in the large intestine (5) , and reduce intestinal damage overall (6) .
- However, most of these studies were conducted on animal subjects . There is no substantial evidence that CBD can alleviate ulcerative colitis symptoms in humans.
- Seeking advice from a medical professional, particularly someone experienced in cannabis use, is best for individuals who want to take CBD for UC.
Why Some People Are Turning to CBD for Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and causes long-lasting ulcers, or sores, in the digestive tract.
UC affects the inner lining of the large intestine (microscopic colitis), causing a person to experience bowel movements frequently.
UC commonly affects adults aged thirty to forty years old and is said to account for about $8 to $15 billion in total economic burden in the United States (7) .
The cause of this type of inflammatory bowel disease ( IBD ) is not clear. However, researchers believe colitis develops in genetically susceptible individuals as a response to environmental triggers.
Although there is no known cure for ulcerative colitis, doctors may prescribe treatment to reduce the inflammation that causes its symptoms.
Aminosalicylates have been the main form of treatment for the disease for many years. A physician could also prescribe corticosteroids or antibiotics (8) .
A new approach that could potentially alleviate the symptoms of ulcerative colitis is the use of CBD (cannabidiol). Studies have shown that CBD’s anti-inflammatory properties may help treat UC (9) .
Cannabidiol is one of the many chemical compounds present in the Cannabis sativa plant, which could be hemp or marijuana.
Compared to delta-9-tetrahydrocannabinol ( THC ), which is predominantly found in marijuana, CBD from hemp is non-intoxicating and does not cause a high when consumed (10) . Meanwhile, the use of cannabis (marijuana) induces psychoactive effects.
A study published in 2009 in the Journal of Molecular Medicine found that cannabidiol may have protective effects in rats with colitis (11) .
The researchers examined the large intestines of the subjects and found that CBD was able to reduce injury in the general area.
Another study on rats with ulcerative colitis was carried out the following year to learn about CBD’s effects on this type of IBD.
Results revealed that THC and CBD inhibited inflammation and functional disturbances in the large intestines of the rodents (12) .
The results of these two small studies led another team to continue examining CBD and how it affects colitis in animal models.
In a 2011 study published by the scientific journal PLOS One , scientists once again found that CBD reduced intestinal damage in mice with colitis (13) .
Meanwhile, a clinical trial found that applying CBD as a topical can improve colonic inflammation in mice with UC (14) .
Despite these positive results, most of the studies on CBD’s effects on colitis were carried out on rodents. However, at least one clinical trial attempted to translate the supposed health benefits of CBD on human subjects with UC.
The study compared the effectiveness of CBD oil capsules on individuals with UC to another group that was given placebo pills.
The CBD group participants were given 50 mg of CBD capsules twice each day, increasing up to 250 mg twice daily, if tolerated (15) .
After ten weeks, twenty-four percent of the subjects that took CBD claimed to have improved remission rates , stating that they no longer experience colitis symptoms.
Meanwhile, several participants also reported improved quality of life scores compared to the placebo group (16) .
Although appearing to have potential, CBD’s effects on human subjects with ulcerative colitis are unclear. The lack of human studies is why researchers today could not conclude the efficacy of cannabidiol in adults with active UC.
How CBD Oil Works to Help with Ulcerative Colitis
The endocannabinoid system (ECS) is a system present in most mammals and is responsible for regulating several critical bodily functions. Its discovery in the 90s has led many researchers to believe that it could be manipulated to bring about therapeutic effects in parts of the body it controls (17) .
Knowing how the ECS works is essential in understanding how CBD may help alleviate ulcerative colitis and IBD symptoms .
Cannabinoids, like CBD, express their therapeutic effects in the body through receptors in the ECS (18) . The two primary endocannabinoid receptors are the CB1 and CB2 receptors.
CB1 receptors are primarily distributed on neural tissue and the central nervous system. CB2 receptors mediate the functions concerning the immune system .
A study in 2001 mentioned that CB1 receptors are said to play a role in controlling gastrointestinal motility and gastric intestinal secretion (19) . This statement is supported by at least two studies on mice, which demonstrated that CB1 and CB2 receptors are crucial in modulating colonic inflammation (20) .
Although both CB1 and CB2 receptors are considered mediators of inflammation in the ECS, the CB2 receptor seems to be the primary regulator of inflammation and immune functions (21) .
When CB2 receptors are activated, they trigger a response which fights inflammation in the body. This anti-inflammatory reaction is said to help treat chronic inflammatory diseases, one of which is colitis (22) .
CBD supposedly provides its anti-inflammatory benefits by interacting with the cannabinoid receptors in the ECS. Doing so could help treat inflammation of the colon, which is common in ulcerative colitis.
The Pros and Cons of CBD Oil for Ulcerative Colitis
- CBD is said to have anti-inflammatory properties (23) that could potentially alleviate ulcerative colitis and Crohn’s disease symptoms .
- Several studies on cannabis and inflammatory bowel conditions support the concept that compounds, like CBD, can be used to treat inflammatory bowel diseases (24) .
- CBD intake does not result in a euphoric high, unlike THC, which is the psychoactive component prevalent in medical marijuana .
- People can purchase CBD oil products even without a prescription so long as they do so in locations where they are legal.
- According to a study in 2018, cannabidiol is non-addictive and may even help with substance abuse and drug addiction (25) .
- Most of the findings from the studies mentioned earlier were obtained from clinical trials on rodents. At the time of writing, there is no direct evidence proving that CBD can effectively treat ulcerative colitis.
- Research on CBD’s efficacy on human subjects with colitis has shown limited clinical response , with the results of these studies being generally inconclusive.
- People who take CBD may experience adverse effects , such as dizziness, nausea, fatigue, and headache (26) .
- At this time, Epidiolex is the only CBD product approved and evaluated by the United States Food and Drug Administration ( FDA ) (27) .
- The FDA also warns the public that using CBD and other medications together may affect how these drugs work, potentially causing severe side effects (28) .
How CBD Oil Compares to Alternative Treatments for Ulcerative Colitis
Herbal medicines have been used in treating IBDs, like ulcerative colitis and Crohn’s disease . They are said to be effective in alleviating inflammatory bowel disease symptoms in the gastrointestinal tract .
In Italy, complementary medicines, particularly herbal therapies, are frequently used by patients with inflammatory bowel diseases (29) .
Likewise, Chinese literature recognizes the IBD treatment of ulcerative colitis with herbal remedies.
Herbs, such as aloe vera, Boswellia serrata , and turmeric, are often used in the hopes of alleviating the symptoms of colitis (30) .
This belief is based on the alleged anti-inflammatory effects that these herbs provide upon consumption.
Aloe vera is said to have therapeutic potential in treating IBD, based on the positive results of a clinical trial on patients with the disease (31) . Meanwhile, Boswellia serrata (32) and curcumin from turmeric (33) are also reported to have anti-inflammatory activities.
CBD has been shown to possess characteristics that could combat inflammation and help with IBDs, like colitis. There are CBD products available in the form of tinctures and capsules that are infused with herbal medicines.
Users can find CBD oil mixed with herbs, such as aloe vera, Boswellia serrata , and turmeric. There are also CBD supplements in the form of soft gels that contain Boswellia and curcumin.
How to Choose the Best CBD Oil for Ulcerative Colitis
Choosing the right type of CBD oil is imperative to experiencing CBD to the fullest. Three variants of CBD oil are being manufactured by companies today.
The first is full-spectrum CBD, which has all of the chemical compounds that are naturally found in cannabis. This type also has other chemical compounds, like terpenes that provide the distinctive aroma in cannabis plants and flavonoids, which give their unique colors.
Full-spectrum CBD also contains trace amounts of THC, which cannot cause a psychoactive reaction.
Combining all of these compounds and consuming them provides the user with the entourage effect. This effect means that the cannabis constituents are more effective when consumed together compared to taking them individually.
Cannabidiol is not the only compound of cannabis that is said to have therapeutic effects. When choosing a CBD product, users often decide to select one containing the full range of cannabinoids to maximize their health benefits .
The second type of CBD oil is called broad-spectrum, which is similar to full-spectrum. It also contains all of the phytocannabinoids that are derived from cannabis except THC.
This variety of CBD is ideal for individuals who do not want to consume THC.
The third type of oil is known as isolate, which contains pure cannabidiol. Users that are allergic to specific cannabinoids of the hemp plant, or those who want to take pure CBD, can opt for CBD isolates.
This type of CBD is often available in powdered form but can sometimes be found as crystals.
Regardless of whether a person chooses full-spectrum, broad-spectrum, or isolate, careful consideration is necessary to obtain the best CBD oil suitable for one’s preferences.
Here are several tips to ensure that high-quality, safe, and reliable cannabis products are bought today:
- Look for the certificate of analysis (COA) or the laboratory report of the CBD product selected. This document is especially important since it indicates that the item has undergone thorough testing and contains precisely the specifications listed on its label.
- Read up on product and shop reviews when buying from an online store. If purchasing from a physical dispensary, check if it has proper authorization to sell CBD.
- Only buy organic CBD derived from hemp. The hemp plant is the most reliable source of quality cannabidiol.
- Ensure that the legalities involving CBD are followed in the state where it is planned to be bought and used.
- Consult a medical professional, preferably someone experienced in medical cannabis , before deciding to use CBD for the symptoms of ulcerative colitis.
Additional Tips to Get the Best CBD Oil Products
- Keep an eye out for CBD brands claiming that their CBD is acquired from the stalk and seeds of hemp plants. Cannabidiol is not found in hemp seeds, and there are minimal traces of CBD in the stalks of hemp.
- Do not purchase CBD vape cartridges containing thinning agents, such as propylene glycol and polyethylene glycol, as these can be toxic and harmful to one’s health.
- Avoid purchasing low-quality CBD edibles and gummies that are made of artificial colors and sub-standard ingredients.
- Contact CBD brands directly for any questions or concerns. Try another CBD company if they do not respond.
CBD Dosage for Ulcerative Colitis
There are no official guidelines concerning the consumption of CBD for ulcerative colitis. However, it might help to review the dosage of past human clinical trials to have an idea concerning the safe amount for intake.
From the study mentioned earlier, patients with UC were given 50 mg of CBD oil capsules twice a day. The participants who tolerated it well took increasing amounts, reaching as much as 250 mg twice per day for ten weeks.
The study showed that the subjects who took CBD felt better and claimed to no longer experience colitis symptoms. A few individuals also reported mild reactions, such as dizziness and nausea.
A systematic review of CBD dosing found that patients who took doses between 1 and 50 mg/kg per day reported significant improvements in their conditions (34) . This review took into account the results of twenty-three studies and found that CBD was well-tolerated in all subjects.
Perhaps the best rule to apply with regards to CBD dosage is to start with a small amount and then observe its effects. If there are no severe reactions, users can gradually increase their dosing until they experience the desired outcome.
How to Take CBD Oil for Ulcerative Colitis
When seeking the anti-inflammatory effects of CBD for colitis, users can choose to take CBD sublingually via tinctures and droppers. This approach involves placing drops of CBD oil under the tongue and keeping it there for several seconds before swallowing.
Applying CBD by way of tinctures is probably the fastest way to deliver cannabidiol to the body as the compound can enter the bloodstream immediately.
CBD in capsule form is also another way to take cannabidiol, allowing individuals to take them daily, similar to supplements.
Meanwhile, users can find CBD edibles in the form of cookies and gummies that can be consumed as snacks.
This kind of product is usually available in various flavors and can be a delightful introduction to CBD. However, edibles can take effect longer than other forms of CBD, as it has to travel through the gastrointestinal tract first.
Ulcerative colitis is an inflammation of the colon that primarily affects the lining of the large intestine , causing people to experience frequent bowel movement or flare-ups .
UC commonly occurs in adults between the ages of thirty to forty years old and is reported to be a significant economic burden in the United States.
There is no clear indication of what causes colitis and, as of this time, scientists have not yet found a cure for the disease.
Aminosalicylates are the most prescribed treatment for UC, with doctors aiming to reduce inflammation and improve the quality of life of IBD patients.
Several studies have shown that CBD is a possible medical treatment option for ulcerative colitis and other inflammatory bowel conditions. Researchers discovered that CBD could prevent injury and inflammation to the colon, potentially providing relief for colitis disease activity .
Experts believe that CBD may reduce inflammation by interacting with the CB1 and CB2 receptors of the ECS.
However, most randomized controlled trials were carried out on animals, with no direct evidence showing that CBD is an effective treatment for UC symptoms in humans .
When deciding to purchase CBD for intestinal inflammation , interested cannabis users should consult a doctor to get the right medical advice.
People can benefit from visiting a healthcare provider experienced with cannabis oil and CBD .