500 Mg CBD Oil Dosage

500 Mg CBD Oil Dosage There isn’t one dosage that will work for everyone, but there are general guidelines. T he U.S. Food and Drug Administration doesn’t have recommendations on how much to CBD dosage can make a huge difference on whether CBD oil works for you. Learn how to calculate dosage and decide which concentration is the right for you. CBD can be ingested and absorbed in a few different ways. Each method has its advantages and disadvantages. Learn more about CBD dosing here.

500 Mg CBD Oil Dosage

There isn’t one dosage that will work for everyone, but there are general guidelines. T he U.S. Food and Drug Administration doesn’t have recommendations on how much to take, but e xperts generally recommend 1–6 mg per every 10 lbs of body weight. For example, if you weigh 100 lbs, you could take 10–60 mg daily. The chart below is a handy reference for how much you might start with. You can also use our CBD dosage calculator to quickly find your results.

Weight and dosage 100 lbs 150 lbs 200 lbs 250 lbs 300 lbs
1 mg 10 mg 15 mg 20 mg 25 mg 30 mg
2 mg 20 mg 30 mg 40 mg 50 mg 60 mg
3 mg 30 mg 45 mg 60 mg 75 mg 90 mg
4 mg 40 mg 60 mg 80 mg 100 mg 120 mg
5 mg 50 mg 75 mg 100 mg 125 mg 150 mg
6 mg 60 mg 90 mg 120 mg 150 mg 180 mg

CBD products are available in varying doses and sizes. Some products that appear to be large in size aren’t necessarily a large dose of CBD. Remember to check how many milligrams are in each serving.

How much you should take will depend on lots of factors, including your age, your sex, the reason you’re taking it, your metabolic rate (how quickly you metabolize compounds), and the quality of the product

If you’re taking CBD for a serious case of insomnia, or some other condition such as anxiety or depression, you may need to be in the higher range of recommended use. Speak to your doctor about how much you can start with, especially if you have any medical condition. CBD may interact with other drugs that you’re taking, so talk to your doctor to make sure there aren’t any drug interactions.

How to Calculate Dosage If Not Labeled

Capsules and gummies will tell you exactly how many milligrams of CBD are in each serving. With oils or sprays, it may or may not tell you how much CBD is in each drop or spray. If it doesn’t, then you have to do a little math.

Each drop is .05 mL, so if you have a 10 mL bottle, the bottle will contain 200 drops. You work this out by dividing the size of the bottle by the number of drops. If the bottle contains 500 mg of CBD, it will give you 2.5 mg of CBD per drop (500 mg divided by 200 drops). If you want to take 25 mg of CBD, you will take ten drops.

Recommended Dosage

Increasing Your CBD Dosage

It’s a good idea to start slow. Begin on the lower end of the CBD dosage to make sure that you don’t have a negative reaction. CBD has been found to be generally safe, and occasionally users report appetite changes, fatigue, and diarrhea.

Keeping a record of how much you take and how you feel can also be helpful. If after a few days you aren’t feeling much effect, you can slowly increase your dosage. If you’re taking CBD to improve your sleep, track how long it took you to fall asleep, how many times you woke up during the night, how long you slept, and how you felt when you woke up.

One of the best ways to track your sleep is with a sleep app. I’ve tested out several, and my favorite is Sleep Cycle. Besides tracking a lot of basic information about your sleep, it has a great feature where you can add “sleep notes,” such as “30 mg CBD,” “40 mg CBD,” etc. Every night you can check off the relevant sleep note to mark what you did that day, and it will track how well you’re sleeping with each of the different notes. For example, I can see that when I eat a lot of sugar during the day, my sleep quality decreases by 15%. When I take 120 mg of CBD, my sleep quality increases by 20%. When I take 50 mg of CBD, my sleep quality increases by 10%.

It also takes people different amounts of time to experience the effects. There are many reported benefits of CBD, such as pain relief, stress relief, being able to fall asleep faster and sleep deeper, but one of the most common effects of CBD is a sense of calm. Some may feel it within an hour; for some, it may take a few days or even a few weeks. If you don’t notice anything after a week, increase your dose. If you are pretty sensitive to supplements, you may increase the dose every few days until you start noticing benefits. There are no guarantees that you will feel anything different, but you have to give it time.

Another factor is how often you take CBD. Instead of taking your daily intake in one dose, experiment by dividing it in two and taking it twice per day to see if you feel more benefits. As CBD stays in your system for 4–6 hours, you may find it helpful to take it two or more times per day.

What Are the Best Ways to Take CBD?

There are a lot of ways to take CBD, including capsules, tincture, spray, added to a drink, creams, lotions, candy, and in a vape.

If you want to know exactly how many milligrams (CBD dosage) you’re taking, the best way is the capsule (or a gummy) as the bottle will tell you exactly how much is in each capsule. If you’re using a tincture, it’s more difficult to get the exact dose you’re looking for. Another benefit of capsules is that there’s no taste. With tinctures, you can taste more, and the flavor isn’t always great.

The fastest way to feel the effects is to use a tincture or spray. Place the CBD under your tongue and let the mucous membranes in your mouth absorb it for 60 to 90 seconds. Many people will feel the effects in around 20 minutes. If you take it in a capsule, or if you swallow a CBD liquid, it has to pass through your digestive system and be metabolized by your liver, so it could take an hour or two. Using CBD topically is better for dealing with chronic pain in a specific area.

Speed isn’t necessarily the most important factor in choosing how to take CBD. For some people adding it to their drink or smoothie is the most convenient, and for others, a capsule is best. No matter which way you choose, it’s a good idea to time it for the best effect. If you’re taking it to sleep better, you may want to take a capsule a couple of hours before bed, or a tincture 20 minutes before bedtime.

Understanding Quality

Make sure that you’re taking a high-quality CBD product. If you’re not, it will reduce the chances of you experiencing the benefits, and in rare cases, could cause you harm. Hemp is a bioremediator, meaning that it can extract toxins out of the soil. It was used by farmers in Chernobyl after the nuclear accident to help clean the soil.

High-quality brands will include a certificate of analysis (COA) that shows all of the third-party testing that has been done on the product to make sure that it’s free of toxins and other contaminants.

Can CBD Help You Sleep Better?

There’s a lot of research being done right now on insomnia and CBD, and the results so far are positive. Research published in the National Institutes of Health (NIH) found that when 160 mg of CBD was administered to subjects, they reported sleeping significantly more than those who took a placebo. Another study in the Journal of Pharmacology found that CBD increased sleep time in rats. Yet CBD administered during the day increased the amount of time to fall asleep, suggesting that CBD can make you more awake during the day.

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It’s no surprise that CBD can help you get to sleep faster, stay asleep, and get more restful sleep as there are many conditions that CBD is reported to benefit, including, anxiety, depression, joint pain, COPD, diabetes, heart disease, and substance abuse.

Many researchers believe that there’s a connection between CBD’s benefits for reducing anxiety and increasing sleep.

There’s a lot of research being done on CBD as it’s become popular since the Farm Bill was passed. In 2018 the United States Food and Drug Administration (FDA) approved the first CBD-based treatment to help control epileptic seizures in Lennox-Gastaut syndrome and Dravet syndrome. There may be more CBD-based products approved by the FDA in the future.

On February 19, 2021, the Journal of Cannabis Research surveyed 522 adults that use cannabidiol. Below are the responses when asked “how does cannabidiol affect your sleep?”

How Does CBD Affect Your Sleep?

Moltke, J., Hindocha, C. Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems. J Cannabis Res 3, 5 (2021).

Does CBD Make You High?

THC ( tetrahydrocannabinol)is the compound in marijuana that makes people high. Though CBD and THC come from the same plant, CBD doesn’t cause a person to get high. Some CBD products have trace amounts of THC (3% or less), but research from the Netherlands suggests that CBD can counteract some of the effects of THC. Some marijuana growers have even developed strains containing higher levels of CBD that make for a much milder high.

Will You Fail a Drug Test?

As CBD won’t make you high, it won’t cause you to fail a drug test. THC can affect a person’s mood, coordination, time perception, concentration, and memory, and even cause hallucinations. Occasionally THC can cause negative side effects including anxiety, rapid heart rate, and short-term memory recall issues. CBD doesn’t have the compounds that cause these effects.

If someone was taking a large amount of CBD, over 1,000 mg per day, they could trigger a false positive on a drug test. Most people take between 100 mg and 200 mg per day.

Side Effects

There are few known side effects of taking CBD. Those who do experience negative effects will have changes in appetite, fatigue, or diarrhea.

CBD can interact with other pharmaceuticals, so if you plan on using it, speak to your doctor. CBD can interact with any drug metabolized by cytochrome P450 enzymes, which can include:

  • steroids
  • immune modulators
  • benzodiazepines
  • antiarrhythmics
  • antibiotics
  • angiotensin II blockers
  • oral hypoglycemic agents
  • sulfonylureas
  • anesthetics
  • antipsychotics
  • HMG CoA reductase inhibitors
  • calcium channel blockers
  • antihistamines
  • prokinetics
  • HIV antivirals
  • antidepressants
  • antiepileptics
  • beta-blockers
  • PPIs
  • NSAIDs

Is CBD Addictive?

According to the National Institute on Drug Abuse, CBD isn’t addictive, and when someone stops using it, there are no withdrawal symptoms.

How CBD Works

CBD prevents the stress response that starts in the brain by activating the adenosine receptor in our endocannabinoid system, which controls the physiological response to stress called the hypothalamic-pituitary-adrenal axis (HPA). This process starts when the brain perceives something that it believes could cause us harm.

The first part of the chain is the amygdala, which contributes to emotional processing. The amygdala signals the hypothalamus which then signals the adrenals and the rest of the body. The adrenal glands send adrenaline into the body to make the heart beat faster, the muscles and organs receive more blood and oxygen, the brain receives more oxygen, and glucose and fat are released into the bloodstream. The person is now able to run faster or fight harder as they have more energy and are more aware.

When someone has chronic, low-level stress, they’re unable to sleep because this stress response is preparing them to run and/or fight, not sleep. Researchers believe that this may be the main way that CBD helps insomniacs get to sleep, by reducing or shutting off the HPA stress response.

How to Store CBD

Like many other oils, CBD can break down when exposed to heat, oxygen, or light, hence many CBD products are in dark brown or colored containers. The best place to store your CBD products is in a cool and dark place (a refrigerator is a good option). If you don’t expose your CBD products to heat, oxygen, or light, most products will last up to a year.

CBD Dosage Frequently Asked Questions

Here are the answers to the most frequently asked questions we receive about CBD dosage.

The U.S. FDA doesn’t have recommendations on how much to take, but experts generally recommend 1-6 mg per every 10 lbs of body weight. If you weigh 100 lbs, you could then take 10-60 mg daily.

Start with a low dose to make sure that you don’t have any negative reactions. If after a few days you aren’t feeling much effect, you can slowly increase your dosage.

If you want to know exactly how many milligrams of CBD you’re taking, capsules are the best. If you want to experience the effects the fastest, using a spray or tincture is best.

Research published in the National Institutes of Health (NIH) found that when 160 mg of CBD was administered to subjects, they reported sleeping significantly more than those who took a placebo.

THC is the compound in marijuana that makes people high. Though some CBD products have trace amounts of THC (3% or less), CBD counteracts the effects of THC. And CBD oils without THC are also available.

If someone was taking a large amount of CBD, over 1,000 mg per day, they could trigger a false positive on a drug test. Most people take between 100 mg and 200 mg per day.

According to the National Institute on Drug Abuse, CBD isn’t addictive, doesn’t cause a high, and when someone stops using it, there are no withdrawal symptoms.

CBD prevents stress that starts in the brain via the adenosine receptor in our endocannabinoid system, which controls the response to stress called the hypothalamic-pituitary-adrenal axis (HPA).

CBD oil dosage (Video): Which CBD concentration is right for me?

One question we hear a lot at Populum is “How much CBD hemp oil should I take?” Our best answer for calculating CBD dosage is that it varies for each individual. That might sound like a cop out, but like any other health or wellness product, what you need versus what someone else might need depends on a variety of factors. That being said, we have few things for you to think about before jumping in.

Here at Populum, we offer full-spectrum hemp CBD oil tinctures in four different concentrations:

In many ways, all of our CBD hemp oil concentrations will provide you with the same experience.

You’re getting the same quality and quantity of CBD oil in each bottle.

The only difference is the strength of the oil. Regardless of concentration, every single batch is extracted from the highest quality hemp, grown by farmers right here in the USA. All batches are tested through the same third-party lab, and you’ll receive those results in your box. It’s then packaged at a GMP Certified facility, where each offering is placed in the same 1oz bottles. The suggested serving size of 1ml is consistent across all bottles, each containing around 30 servings.

They all offer our delicious orange flavor.

When we started Populum, we found that one of the most common deterrent against trying CBD hemp oil was that people don’t enjoy taking bitter supplements. Most CBD oils have a strong earthy taste, so we worked on creating a subtle and delicious orange flavor that makes for a more pleasurable experience administering the oil every day. No matter the strength of CBD in your hemp oil, you’ll be tasting a sweet orange essence rather than dirt.

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How do I calculate CBD oil dosage with each concentration?

If you’re unfamiliar with CBD hemp oil, it can be really confusing when deciding where to start. So how do you differentiate between the levels of concentration, and what’s the right choice for you? Simply put, you just divide the bottle’s total concentration by the amount of serving it has. For example, our 250mg bottle has 30 servings, so (250mg / 30 servings) = ~8mg / serving!

Here’s a more detailed breakdown:

250mg: This is a great option if it’s your first time trying CBD hemp oil. As the lowest concentration, the Basic 250 allows you to test out CBD at a safe, low dosage. The Basic 250 contains 8mg of CBD per serving, and many people experience the wellness benefits of CBD at this level

500mg: This is our most popular offering, and a great way to experiment with dosage. If you’re truly lost as to where to start, a half-serving of the Signature 500 will give you the same dose of CBD as our Basic 250, and two droppers is equivalent to a serving of the Advanced 1000. At this level, you have plenty of room to figure out what the best level of concentration is for your needs and decide which bottle to purchase next. The Signature 500 contains 17mg of CBD in each serving, and is a top choice amongst our subscribers who have established a daily regimen of CBD hemp oil

1000mg: Sometimes you just need more. This is one of the highest concentration we offer, and it contains 33mg of CBD per serving. We don’t recommend using the Advanced 1000 as your starting point, but we have plenty of customers who find they just aren’t getting what they need from our Signature 500, and this level offers a little extra.

2000mg: This is the highest potency Populum CBD tincture yet to be added to the lineup. Developed as a result of consumer demand, the 2,000mg tincture has 66mg of full-spectrum hemp CBD per serving alongside a healthy mix of naturally occurring rare cannabinoids like CBN, CBG, and CBC.

Feel Better with Populum CBD

The best CBD oil you can buy, backed by 900+ verified reviews from real customers.

Then What?

Ultimately we want to make sure that whichever option you choose, you’re able to give it a real, honest try before you commit. All our bottles come with a 30-day, risk-free trial. You can use your bottle for 30 days – you can even finish it – and if it just doesn’t work for you, we’ll refund your purchase, no questions asked. What’s more, we want to make sure you have the assistance you need; from the time you choose where to start, your experience as you try out different doses, and all the way through your subscription decision, we make ourselves available to you when you need us. We have dedicated customer service representatives standing by who are ready to answer your email, chat, or phone call whenever you need some suggestions. This is about you and your wellness, and we’re here for you every step of the way.


It seems like CBD oil can be found just about anywhere nowadays. At the corner drugstore, your favorite supermarket, your trusted online retailer… it’s not difficult to spot. What’s more challenging, however, is finding appropriate dosing information to meet your needs.

An important note before we dive in: So far, there isn’t any reliable research to support a so-called “universal ideal dosage” for CBD — and this notion is also reflected in what you see across the CBD market itself. For all the CBD products out there, there’s also a wide range of recommendations on how much and how often one should use CBD.

Since there are no “standard” dosages, it’s therefore up to each of us to discover the ideal amount of CBD that works for our body.

There are several reasons why it’s so difficult to make a precise recommendation for CBD dosage, and we’ll cover them in just a moment.



As soon as CBD reaches your bloodstream, regardless of the route, it acts upon your body’s endocannabinoid system, or ECS for short. To put it very simply, the ECS regulates processes like mood, appetite, pain management and inflammation, and ensures that your bodily functions remain in optimum balance, a concept otherwise known as homeostasis.

The exact effects and the extent to which CBD affects your ECS depend on a wide range of factors, such as your weight, diet, metabolism, general health, other medications you take and, last but not least, your genes.

So, when we consider that each and every one of these factors affects how your body reacts to CBD, it’s easy to see why general dosage guidelines are so difficult to provide to any given person. To make matters worse, many argue that not enough scientific research is being done on CBD to begin with, which means we’re not getting any closer to understanding how these factors affect CBD.


Now that we’ve got all that out of the way, we can finally get to what everyone wants to know: How much CBD should I take?

Again, there is no clear answer to this key question. Every person reacts differently to CBD and, depending on the product and form of administration, the results can vary greatly. However, with a few simple steps and rules of thumb, you can hopefully find the CBD dosage that works best for you.

Step 1: Determine the strength of your CBD oil

Many manufacturers make this easy because they clearly state how many milligrams of CBD are in each serving (drop, pump, spray etc.) of the total bottle. If the label does not include that information or any details about the concentration of your CBD oil, you’ll need to do the calculation yourself. (It’s quick, we promise!)

For that, you’ll need the following numbers:

  • Bottle size in milliliters (ml)
  • CBD content in milligrams (mg; for example, 200 mg, 500 mg, 1,000 mg, etc.)

Then, we calculate the CBD concentration using this basic formula:

CBD content in mg ÷ bottle size in ml = CBD mg per ml

Let’s assume a manufacturer sells a 10 ml bottle of CBD oil that contains 500 mg of CBD. Thanks to our formula, we can calculate that 500 mg ÷ 10 ml = 50 mg CBD / ml. One milliliter of oil, therefore, contains 50 milligrams of CBD.

Great, but now how do we tie milliliters to actual drops of oil?

Step 2: Determine the amount of CBD per drop (serving size)

Most vials of CBD oil come with their own pipette or dropper to dose out drops. In order to find out how much CBD is in each drop, you’ll need to know how many drops are in a full pipette. Some CBD oils already provides this information on the packaging, but if not, here’s where this step comes in.

(For CBD sprays, make sure the manufacturer states how much CBD is in each spray or pump, as the following calculation does not work with sprays.)

Usually a full pipette will hold about 1 ml of oil, but sometimes it’s a little less. Fill the pipette completely with oil and count how many drops there are in the pipette. (Remember to drop the oil back into the vial so it doesn’t go to waste!) The amount of CBD per drop can then be calculated with this formula:

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CBD mg per ml ÷ Number of drops in 1 full pipette = CBD mg per drop

Let’s say your pipette contains 40 drops and the bottle contains 50 mg CBD per ml. That means that 50 mg CBD ÷ 40 drops equates to 1.25 mg CBD per drop.

Step 3: Approach the Dose That Works for You

Those who have never used CBD before might want to start with a low dose of 5 mg per day. The exact number of drops depends on the oil you’re using and the calculations made in Steps 1 and 2.

(In the above example, with a 10 ml bottle of 500 mg CBD, 50 mg CBD per milliliter and 1.25 mg CBD per drop, a 5 mg dose of CBD would equate to about 4 drops of CBD oil total per day.)

This amount is then increased by small increments over time until you have achieved the effect you want. While side effects are rare and usually quite harmless, CBD can make some people feel quite sleepy, so you might want to take your first doses in the evening, or at least not before an important meeting or a long drive.

Day 1: 5 mg per day

Day 2: 5 mg per day

Day 3: 5 mg per day

Day 4: 10 mg per day

Day 5: 10 mg per day

Day 6: 10 mg per day

Day 7: 15 mg per day

And so on until you’re satisfied with the dose.

Remember to be patient and not to increase your dose too quickly, as it can take many people several weeks at a consistent dose of CBD before they feel an effect.

How much CBD is recommended per day?

People who take CBD regularly tend to take between 20 and 100 mg per day, but the amount that works for you will, of course, depend on the effect you seek with CBD and how your body reacts to it.

If you experience side effects such as headache, slight drowsiness, dizziness, loss of appetite, diarrhea or nausea/vomiting, it probably means that you increased your dose too quickly or exceeded the dose that works best for your body, which is why it might be a good idea to go back down to a lower dose until you feel better. Here you can find more information about possible side effects with CBD.

Start low and slowly work your way up — and don’t forget that oftentimes with CBD (and so much else) less is more.


CBD can be ingested and absorbed by the body in different ways. Each method has its advantages and disadvantages, and often simply comes down to your personal preferences. More information about the various intake methods can be found here.

CBD is now available in almost every dosage form, and new products like CBD coffee are constantly being added to the list of available CBD products, of which the most well known is probably CBD oil.

Oral CBD

Dozens, if not hundreds, of brands offer CBD oils in a variety of formulations and flavours. The vial usually comes with a pipette that’s used to put the oil directly under your tongue. Yet dosing with pipettes is often cumbersome and imprecise, which is why some brands, and we at VAAY, offer CBD sprays instead. A practical spray bottle head simplifies the dosage and intake of the oil considerably.

For those who aren’t fans of the earthy taste that hemp often has or prefer something different, some brands offer CBD capsules. Often these capsules are gel-filled, which means they’re pre-dosed, and they can be taken easily and inconspicuously on-the-go, usually without any unpleasant aftertaste.

With regard to these oral administration methods, it should be noted that CBD first has to pass through the stomach and liver before it reaches the bloodstream. This increases the time it takes for CBD’s effects to take hold, but they also last the longest with this method of administration (up to 6 hours).

Topical CBD

Many people use CBD topically in the form of CBD ointments, CBD lotions, CBD creams and CBD gels to treat muscle aches, pain from arthritis, inflammation and other issues related to skincare. When CBD is applied locally, the effects can often kick in faster than when CBD is taken orally. This is because the CBD in topical products is absorbed through the skin precisely in the affected area, where they then interact directly with the skin’s cannabinoid receptors. Depending upon the exact formulation, the dosage can differ from product to product and it’s usually specified on the package.

Inhaled CBD

CBD can reach your bloodstream the fastest is when it’s inhaled through your lungs, via vaporiser or CBD diffuser pen. (Smoking cigarettes with CBD falls into this category too, however due to the lung damage that results from combustion, smoking is not recommended under any circumstances.)

Bioavailability is highest when CBD is inhaled (approx. 31%), which means that you can receive more of an effect with a lower dose than you would with other forms of administration. In other words, the effects might be stronger, even thorough the dose is smaller.

For example, if you typically take 10 mg of CBD via drops and you want to try vaping, you might want to cut the dose in half and inhale just 5 mg until you know how it affects you.

Whereas orally ingested CBD might take an hour to kick in and hours to wear off, CBD that’s inhaled can take hold in just minutes but its effects will also diminish more quickly too. For a long-lasting effect, it is best to combine inhaled CBD with an orally ingested form of CBD.


At first glance, the idea that all CBD is the same seems logical. For example, Vitamin C supplements are practically indistinguishable from brand to brand, so in the end, all kinds of CBD work the same way too, right? But appearances can be deceptive.

CBD is one of 100+ cannabinoids that occur naturally in cannabis and hemp plants. However, before CBD can be processed into an end product like CBD oil, cream, capsules, bath balls and beyond, it must be extracted from the plant. There are various extraction methods that a given manufacturer can use, and the extract obtained can be either a full-spectrum extract, a broad-spectrum extract or a pure CBD isolate.

As the name suggests, a full-spectrum extract reflects the full range of all components (other cannabinoids and terpenes) found in the particular plant from which the CBD was extracted. A broad-spectrum extract is similar, except the THC is completely removed. The terms themselves “full-spectrum” and “broad-spectrum” are often mixed up because most hemp plants contain negligible amounts of THC anyway and so there’s no need to use a separate word to refer to hemp extracts without THC.

However, calling out the difference with CBD isolate is important because these finished products contain only pure CBD and no other components from the plant. This can have its advantages: manufacturing is often easier and the end product is often cheaper for the consumer. However, studies suggest that when it comes to effectiveness, CBD isolates don’t hold a candle to full- or broad-spectrum extracts. In addition, there is some evidence to suggest that CBD might have a synergistic relationship with other plant elements, resulting in a so-called “entourage effect” in the body.

How exactly a manufacturer extracts its CBD and how it is processed makes a big difference and influences how the finished product works for you. So you see, not all CBD is created equal.